The EMBO Journal · @embojournal
451 followers · 193 posts · Server sciencemastodon.com
How do #botulinum toxins get to nerve ends to mediate #neurointoxication?
F. Meunier Lab shows that BoNT/A uptake into #synaptic #vesicles is via hijacking of a tripartite membrane nanocluster of #polysialogangliosides, #synaptotagmin and glycoprotein SV2
https://www.embopress.org/doi/10.15252/embj.2022112095
#botulinum #neurointoxication #synaptic #Vesicles #polysialogangliosides #synaptotagmin
The EMBO Journal · @embojournal
406 followers · 91 posts · Server sciencemastodon.com
Extracellular #vesicles from #Zika #virus-infected cells display viral E protein that binds #ZIKV-neutralizing #antibodies to prevent infection enhancement
https://www.embopress.org/doi/10.15252/embj.2022112096
#Vesicles #zika #Virus #zikv #antibodies
preLights · @preLights
516 followers · 92 posts · Server mstdn.science
To move or not to move: A novel in vitro assay successfully recreates intracellular bidirectional cargo transport.
First #preLight from Divya Pathak who covers a #preprint from the Diez and Santen labs, led by Ashwin D'Souza. Includes comments from the preprint authors š
#prelight #preprint #Vesicles #transport #cytoskeleton #dynein #kinesin
Vivek Mutalik · @vivek_mutalik
601 followers · 550 posts · Server fediscience.orgA Universal Strategy to Promote Secretion of G+/Gā Bacterial Extracellular #Vesicles and Its Application in Host Innate #Immune Responses
#microbialcommunity #microbiome #delivery #payload #synbio #immune #Vesicles
Joseph P. · @tonic
229 followers · 118 posts · Server mstdn.science#Osteoblasts are cells that are responsible for the formation of #bone. They do this by modulating the composition of the #BoneMatrix, which is the material that makes up the bone. Osteoblasts deposit minerals, such as #calcium phosphate hydroxyapatite, in the matrix. This process is thought to be mediated by the release of matrix #vesicles, which are small fragments of the cell membrane.
#osteoblasts #bone #bonematrix #calcium #Vesicles
Michael Booth · @mikebooth
202 followers · 74 posts · Server mstdn.scienceI'm going to be giving a talk at this week's MRS fall meeting (Monday, 11am) on our work developing methods to control synthetic cells, at symposium SB11!
Lots of #DNA #photocages #cellfree #vesicles #synbio #DNAlogic
bit.ly/3OzjtFE
If you're there please come and check it out! #f22mrs #mrs22 #SB11
#DNA #photocages #CellFree #Vesicles #synbio #dnalogic #f22mrs #mrs22 #sb11
Julien Delpierre · @JulienDelpierre
180 followers · 214 posts · Server qoto.org
I came across this #microscopy paper. https://www.nature.com/articles/s41587-022-01519-4
"By blue-shifting the #STED beam and separating #fluorophores by on/off switching, individual fluorophores bound to a #DNA strand are localized with Ļā=ā4.7āĆ
, corresponding to a fraction of the fluorophore size, with only 2,000 detected #photons ."
This image showing resolution below the size of the fluorophore leaves me speechless.
The paper features images of #DNAorigami, #NuclearPores, synaptic #Vesicles, #ECM (#laminin) and #vilmentin
#Sted #dna #microscopy #photons #vilmentin #Vesicles #fluorophores #DNAorigami #NuclearPores #ecm #Laminin