Data presented by @tajiknia shows MRTX1133 suppression of pERK at nM doses & synergies with 5-FU in CRC & pancreatic cancer cells with G12D, G12V, & G13D. More studies needed before excluding non-G12D mutations from trials @BrownUCancer @BrownMedicine

#aacrjca22 #KRAS #eldeirylab

Last updated 2 years ago