How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
https://www.embopress.org/doi/full/10.15252/embj.2022112812

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Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !