C12H22011 · @SweetAdmixture
16 followers · 177 posts · Server toot.community

Recently started a quest to get rid of or reduce my intake.

Looking through internet I found butterfly pea flower tea (apparently there's a lot of hype about it) and one of the things that hype says is that is great for people with anxiety, depression and . So I said, let's read a little bit more.

contains and information about it says this:

Lesson learned? Don't follow the hype, do your research and always talk with your doctor.

#caffeine #adhd #butterflypeaflower #acetylcholine

Last updated 2 years ago

Kevin Pho, MD · @kevinmd
238 followers · 119 posts · Server med-mastodon.com

My journey with myasthenia gravis: a chronic autoimmune disease

Myasthenia gravis is a chronic autoimmune neuromuscular disease that causes weakness in the skeletal muscles, which are responsible for breathing and moving parts of the body, including the arms and legs.

Heather Finlay-Morreale is a pediatrician.

youtube.com/shorts/lXaOcmzDG6Q

Listen here: kevinmd.com/podcast

#myastheniagravis #muscleweakness #autoimmune #neuromuscular #acetylcholine #myastheniccrisis #breathing

Last updated 2 years ago

The EMBO Journal · @embojournal
121 followers · 15 posts · Server sciencemastodon.com

What modulates the output of -positive in the mature ?

Kai-Wen He and colleagues reveal rhythmic time- and sleep-dependent regulation via M1 receptors in the mouse primary visual cortex

embopress.org/doi/10.15252/emb

#cortical #parvalbumin #neurons #brain #synaptic #acetylcholine

Last updated 2 years ago

Contemplative Neurosciences · @davidvago
23 followers · 9 posts · Server masto.ai
Scientific Frontline · @sflorg
669 followers · 1678 posts · Server mastodon.social

Disturbed transmission via receptors in chick impairs the hatchlings’ preference for animate objects—similar to what is seen in spectrum disorder in humans.

sflorg.com/2022/11/ns11182201.

#nicotinic #acetylcholine #fetuses #autism #neuroscience #biology #sflorg

Last updated 2 years ago

eSagan 🇮🇳 · @crackurbones
103 followers · 1741 posts · Server qoto.org

🔸 Between two neurons lie the pre-synaptic cell and the post-synaptic cell (cells with the synaptic terminal). They are separated by a short distance called the 'synaptic cleft'.
And the molecules of nerve transmitter are going to make their way from pre-synaptic cell to post-synaptic cell through the synaptic cleft.

🔸 Neurotransmitters need to have a termination, if they are not received by the post-synaptic cell. We use three different mechanisms to terminate the message of a neurotransmitter.

1️⃣ Diffusion: The molecules are simply going to diffuse out if they don't make it to the "ears" of post-synaptic terminal of the receiving neuron. So diffusion is a very effective way to terminate a message.

2️⃣ The second way is through something called re-uptake. And re-uptake is typically in the pre-synaptic terminal. There are channels, or transporters, which take neurotransmitters back up. The neurotransmitters get re-packaged and put back into a new vesicles (which are actually recycled as well).

🔸 And this is really important for drugs like and . And there are drugs that act on the serotonin and dopamine re-uptake transporters that can be used both therapeutically, for instance, to treat depression.

3️⃣ The third way that we terminate a message is through degradation. And in the case of degradation, what we have is enzymes that sit in the synaptic cleft that are just chewing up neurotransmitters. [GIF]

🔸 The molecule that the neurotransmitter where degradation is really important is .
So, in case of acetylcholine, there is an enzyme that sits between the pre-synaptic and the post-synaptic cells, eating up acetylcholine, called acetylcholinesterase (AChE).

🔸 Acetylcholine is the neurotransmitter that is used by motor neurons. And so, in fact, blocking can be used for therapeutics — in the case of people that are not releasing enough acetylcholine, or don't have enough receptors for the acetylcholine.

🔸 We can boost the amount of acetylcholine in the cleft by inhibiting the acetylcholinesterase. And that's useful for people with diseases such as myasthenia gravis.

#serotonin #dopamine #acetylcholine #acetylcholinesterase

Last updated 5 years ago

eSagan 🇮🇳 · @crackurbones
103 followers · 1741 posts · Server qoto.org

🧫 The synaptic terminal has these entities here, which are called synaptic vesicles, and they're small, little organelles.

🧫 They're little vesicles made of a membrane; just like the cell has a cell membrane, these vesicles have a vesicular membrane.
The neurotransmitters are within the vesicular membrane.

🧫 And, the neurotransmitter can be any number of a number of different molecules — , , , , , , , , , .

🧫 The neurotransmitters are packaged in vesicles. The second thing that's important about this is that we can use the synthesis of a as a therapeutic tool.

🧫 So, for instance, Dopamine is missing in .
It's not that dopamine isn't made per say, that's there's a problem with making it — it's that the cells that make it die.

🧫 There's something called 'Mass Effect', which means that you take the starting chemical (the substrate) and then through a series of enzymatic processes reaction, through a series of enzymatic reactions, we end up with a neurotransmitter.

🧫 In the case of Dopamine, what we do to treat in most people with Parkinson's is that we give them the substrate — and so that (drug) is what is commonly known as or .

🧫 So we flood the system with substrate, and the goal is to get a little bit of that neurotransmitter out of the system.

Image source: in.pinterest.com/pin/119627552

#neurotransmitters #glutamate #gaba #serotonin #dopamine #acetylcholine #glycine #norepinephrine #epinephrine #histamine #atp #neurotransmitter #parkinsonsdisease #Sinemet #Parcopa

Last updated 5 years ago

Christina ✅ 🇨🇦 · @cosullivan
1319 followers · 10209 posts · Server mastodon.sdf.org

Hail fellow old people:
alpha-GPC, equivalent to “glycerophosphocholine” is more easily converted into than other forms of . Acetylcholine supports muscular strength, learning, memory, and sustained, focused attention. It is very important for the prevention of age-associated cognitive decline.
I'm not selling supplements nor advocating for a specific way of eating. Just advocating receiving enough choline in your food to slow decline.

#acetylcholine #choline

Last updated 5 years ago