#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

Scientists show that inhibiting an enzyme called NOX2 delays the progression of a common subtype of #AcuteMyeloidLeukemia—hinting that targeting NOX2 could potentiate precision therapies for this deadly blood #cancer. https://scim.ag/2bB @SciSignal #press

Referenced link: https://medicalxpress.com/news/2023-03-car-t-cell-therapy-acute-myeloid.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-car-t-cell-therapy-acute-myeloid.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1635338409299288068#m

RT by @physorg_com: New targets for #CAR-Tcelltherapy against #acutemyeloidleukemia through AI-assisted analysis @NatureBiotech https://www.nature.com/articles/s41587-023-01684-0 https://medicalxpress.com/news/2023-03-car-t-cell-therapy-acute-myeloid.html

Referenced link: https://medicalxpress.com/news/2023-03-blood-acute-myeloid-leukemia-patients.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-blood-acute-myeloid-leukemia-patients.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1633172682505351169#m

RT by @physorg_com: Blood test identifies #acutemyeloidleukemia patients at greater risk for relapse after #bonemarrowtransplant @nih_nhlbi @JAMA_current https://jamanetwork.com/journals/jama/fullarticle/2802059 https://medicalxpress.com/news/2023-03-blood-acute-myeloid-leukemia-patients.html

"Here, we utilized unbiased genetic screens to map drug/gene interactions for a variety of clinically approved therapies used in the treatment of AML. This effort highlighted a unique genetic relationship between response to venetoclax and the function of specific RNA splicing factors."

#AML #leukemia #venetoclax #BCL2 #Apoptosis #RNASplicing #AcuteMyeloidLeukemia

https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8

Recent studies have shown that #AcuteMyeloidLeukemia favors #OxPhos metabolism. This #ASH22 abstract from my colleagues demonstrates with in vitro and in vivo models that the use of #ammocidin, an inhibitor of electron transport chain complex V, works synergistically with low-dose #venetoclax to kill #AML cells. Stop by poster 2652 or read more about it here: https://ashpublications.org/blood/article/140/Supplement%201/5959/492144/Electron-Transport-Chain-Complex-V-Inhibition #leukemia #cancer #oncology #hematology #hemonc #science #medicine

Referenced link: https://medicalxpress.com/news/2022-10-exploring-mechanisms-therapeutic-acute-myeloid.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-10-exploring-mechanisms-therapeutic-acute-myeloid.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1586010495290642432#m

RT by @physorg_com: Exploring novel mechanisms and therapeutic targets for #acutemyeloidleukemia @northwesternu @nature https://www.nature.com/articles/s41586-022-05365-x https://medicalxpress.com/news/2022-10-exploring-mechanisms-therapeutic-acute-myeloid.html