#PopGen #EvolMol #ThalerConference #MustWatch #AlternativeSplicing #SplicingErrors #DriftBarrier Amazing talk by @duret_lbbe here on the SEEM youtube channel 👇

https://ecoevo.social/@couplingdmi/110860290160070455

The #FruitFly gene Dscam1 encodes 19,008 diverse ectodomain isoforms via #AlternativeSplicing. A systematic #CRISPR screen of #Drosophila #Dscam1 reveals both redundant & specific functions of its isoforms in neuronal wiring #PLOSBiology https://plos.io/3PK6V0M

Referenced link: https://medicalxpress.com/news/2023-03-impact-cohesin-mutations-insights-hidden.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-impact-cohesin-mutations-insights-hidden.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1633116408589561866#m

RT by @physorg_com: The impact of cohesin #mutations: Insights into a hidden regulator of #alternativesplicing in leukemia @ScienceAdvances https://www.science.org/doi/10.1126/sciadv.ade3876 https://medicalxpress.com/news/2023-03-impact-cohesin-mutations-insights-hidden.html

Referenced link: https://medicalxpress.com/news/2023-02-compensate-loss-gene-function-alternative.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-02-compensate-loss-gene-function-alternative.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1628121714415570950#m

RT by @physorg_com: How to compensate for loss of gene function? Think #alternativesplicing @BCMHouston https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1219/6976066 https://medicalxpress.com/news/2023-02-compensate-loss-gene-function-alternative.html

Just read "Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans" by Benitiere et al @duret_lbbe, very nice and careful argument that most alternative splicing in e.g. vertebrates is non functional and accumulates neutrally. https://doi.org/10.1101/2022.12.09.519597 #MolecularEvolution #AlternativeSplicing #Neutralism

Studying how #influenza #virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://plos.io/3VnlJS1

RT @PLOSBiology
Studying how #influenza virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://plos.io/3VnlJS1

RT @PLOSBiology
Studying how #influenza #virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://plos.io/3VnlJS1

Studying how #influenza #virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://plos.io/3VnlJS1

Studying how #influenza virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://plos.io/3VnlJS1

Call for papers!

Do you have a story about #AlternativeSplicing, #AlternativePolyadenylation, #RNAmodification, or some other #PostTranscriptional process in #adaptation ?

Please consider submitting to a Special Issue at #Heredity with guest editors Arne Jacobs and yours truly. Deadline end of February 2023.

Email for details.

https://www.nature.com/collections/bjhfcceaeb

Just started my journey at #mastodon.

I'm a lecturer and group leader at the SIB and the University of Applied Sciences and Arts Northwestern Switzerland teaching Data Science in Life Sciences.

I have a background in #Bioinformatics; Worked in #StructuralBiology, #Proteomics, #Interactome, #NGS, #Cancer, #Diagnostics and have a special interest in #alternativeSplicing, #molecularModelling and #clinicalDataScience.

Looking forward to read and share the latest #scienceNews