"Unfortunately, these numbers do not get rid of my doubts. The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any [family member or acquaintance] would be able to notice outside of a controlled clinical trial."

The risk of these anti-amyloid drugs is real and high.

If the effect is to prolong suffering, is it really something you'd want?

#Donanemab #ALZ #Amyloid
https://www.science.org/content/blog-post/lilly-s-alzheimer-s-data-donanemab

Another amyloid target drug, #Donanemab. This drug trial targeted early detection. The news (and the report) says it dramatically slowed (about 1/3rd slower progression) of ALZ. This is measured by cognitive testing. After 3 years, the group taking the drug had a ~33% lower rate of cognitive decline.

In practical terms, it means if you were projected to die in 3 years from #ALZ, you would live 1 year longer (study went 3 years, be careful to extrapolate beyond 3 yrs).

https://jamanetwork.com/journals/jama/articlepdf/2807533/jama_sims_2023_oi_230087_1689286201.27326.pdf

And don't miss Megan on the latest episode of the Readout Loud podcast: https://www.statnews.com/2023/07/13/wegovy-brain-alzheimers-data-leqembi/

#biotech #podcast #obesity #ALZ #Alzheimers

First missive from the #biotech desk:

After leading the company a presumed blockbuster #alzheimers drug, Eisai's head of #ALZ and US operations, Ivan Cheung, 46, to retire.

His brother-in-law and son of Eisai founder, Keisuke Naito, 34, will replace him on ALZ.
https://www.statnews.com/2023/07/11/eisai-executive-who-helped-lead-development-of-alzheimers-drug-to-retire/

Only one problem remains: In the 🇺🇸 it will only be available to the RICH seniors.

___________________________________

https://newsie.social/@brittanytrang/110669152966935502
brittanytrang@newsie.social - BREAKING: #FDA gives full approval to first #Alzheimer’s therapy shown to clearly slow cognitive decline — a milestone in treatment, even if the benefits are modest.

via @STAT's @adamfeuerstein and Damian Garde

https://www.statnews.com/2023/07/06/leqembi-alzheimers-fda-approval-eisai-biogen/

#ALZ #health #healthcare #CMS #medicine #neuroscience #biotech

BREAKING: #FDA gives full approval to first #Alzheimer’s therapy shown to clearly slow cognitive decline — a milestone in treatment, even if the benefits are modest.

via @STAT's @adamfeuerstein and Damian Garde

https://www.statnews.com/2023/07/06/leqembi-alzheimers-fda-approval-eisai-biogen/

#ALZ #health #healthcare #CMS #medicine #neuroscience #biotech

"Drugmakers, after years of failure, are making some strides in slowing the destructive march of Alzheimer’s."

No, they're not. This class of anti-amyloid drugs are failing in one very big way: They're shrinking the size of brain matter and in many cases, causing bleeding in the brain.

#WaPo has failed on #ALZ.

https://www.washingtonpost.com/health/2023/04/24/alzheimers-early-symptoms-treatment/

Women who worked for pay in early adulthood and midlife experienced slower rates of later-life memory decline, regardless of whether they married or had children.

https://www.ncbi.nlm.nih.gov/pubmed/33148811

#HRSData #Cognition #Health #Aging #WorkingWomen #Alz #NICHDimpact

RT @UsAgainstAlz: We want to encourage women to invest in their #brainhealth this #WomensHistoryMonth because not only are women twice as likely to develop #Alzheimers but they're also more likely to be #caregivers. #Alz is a serious women’s issue and women deserve more support. #WomenAgainstAlz

[Share] Deploy #Azure Enterprise-scale for small enterprises (#SMB)! The architecture enables organizations to start as small as needed and scale alongside their business requirements regardless of scale point. #ALZ #LandingZone
https://github.com/Azure/Enterprise-Scale/tree/main/docs/reference/treyresearch

RT @bartlannoeye@twitter.com

Stormy weekend = blog time. Turning #ALZ into multi-stage #azuredevops pipeline (1) and add a review step before deployment (2). #Governance /cc @Jack_Ref@twitter.com
1) https://www.bartlannoeye.com/blog/multi-stage-alz-pipeline/
2) https://www.bartlannoeye.com/blog/multi-stage-manual-approval-pipeline/

🐦🔗: https://twitter.com/bartlannoeye/status/1614285907711893506

Breaking: #FDA approves Eisai-Biogen #Alzheimer's #ALZ drug #Leqembi, also known as #lecanemab: https://www.statnews.com/2023/01/06/fda-approves-alzheimers-drug-leqembi-eisai/

We are looking for a PhD student or postdoc to work with us on characterizing cognitive changes in early Alzheimer's disease using smartphone-based cognitive tests. Please get in touch for questions and apply via the link in the ad https://jobs.dzne.de/de/jobs/101092/phd-student-fmx-or-postdoctoral-researcher-fmx-4059202212 #DigitalBiomarkers #EMA #AmbulatoryAssessment #Alz

Older people with high income and education levels can expect to live a larger portion of their later years without dementia than lower education and lower income people. Time with dementia is compressed for older people with higher income and education level.

https://www.ncbi.nlm.nih.gov/pubmed/34584932

#Alz #Dementia #Cognition #CognitiveHealth #Aging #SES #NICHDImpact @cognition

Haven't properly cleaned since dad passed away earlier this year.
Depression and grief is an indescribable pain. It's not gonna be a cleaning day, it's a weekend's work.

But yeah, please enjoy a pic of my extremely filthy home and emotional/mental state.
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#grief #alz #Alzheimer #Alzheimers #AlzheimersDisease #alzheimersawareness #parentloss #loss #depression #grieving #cleaning #depressoespresso

Do you want to know whats new in the #Azure Enterprise Scale Landing zone? Check out the Whats new wiki page on the git repo! #ALZ https://github.com/Azure/Enterprise-Scale/wiki/Whats-new#november-2022