A new crowdsourced competition seeks more robust early indicators of Alzheimer's disease and related dementias using analytics powered by artificial intelligence.

https://sciencebusiness.technewslit.com/?p=45180

#News #Press #Science #Business #AlzheimersDisease #Dementia #Diagnostics #ArtificialIntelligence #Algorithms #DataScience #Aging #NIH #Challenge #Competition #Crowdsourcing

Gizmodo: An Existing Drug for Multiple Sclerosis Might Be Useful for Alzheimer's Too, Study Finds https://gizmodo.com/ms-ponesimod-might-be-useful-alzheimers-therapy-study-1850803952?utm_source=regular #insulindegradingenzyme #healthmedicalpharma #neuroinflammation #alzheimersdisease #amyloidplaques #amyloidosis #amyloidbeta #macrophages #glialcells #microglia #zhihuizhu #trem2

'While more effective treatments are developed and someday may become more widely accessible, interventions that promote the personhood and well-being of persons living with dementia—as well as that of their care partners and caregivers—will remain integral to dementia care.'
#alzheimersdisease
#alzheimers

https://www.pnas.org/doi/10.1073/pnas.2312272120

#IDMastodaon #NeuroCovid MedSky🧪The more I learned about #SARScoV2🦠 and their destructive doing to the host immunity , the more further distance away that i keep from the crowd & 😷would never leave my face .Especially in the wakes of Eris and Pirola .#CovidIsNotOver . An increasing number of reports suggest an association between #SarsCoV2 infection and initiation or acceleration of #neurodegenerativediseases ( #Alzheimersdisease & #CreutzfeldtJakobdisease )

'While Aβ is clearly the initiating factor in the context of mutations in the genes encoding APP and, likely, presenilin 1 and presenilin 2, I propose that accumulation of pathogenic forms of tau is not a consequence of Aβ in all cases of sporadic AD'
#alzheimers #alzheimersdisease

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(23)00166-2

Alzheimer's Drug Leqembi to be available in some areas in a few months https://politicaliq.com/2023/08/07/alzheimers-drug-leqembi-to-be-available-in-some-areas-in-a-few-months/ #Alzheimer #alzheimersdisease #Leqembi #FDA #Esai #Biogen #Medicare #politicaliq #news #politics

@cellpress TMEM106B is associated with brain aging; myelination disorders; and several neurodegenerative diseases, including #frontotemporallobardegeneration (FTLD), #amyotrophiclateralsclerosis (ALS), #Alzheimersdisease, & #Parkinsonsdisease. Multiple single-nucleotide polymorphisms in TMEM106B have been linked to the severity of these disorders,with an association between risk alleles and increased TMEM106B expression. Different #SARSCoV2 isolates can use TMEM106B for infection

#NeuroMastodon #Neubiology #womenhealth @bmj_company
Dementia affects more women than men worldwide .Menopausal hormone therapy was positively associated with development of all cause #dementia & #alzheimersdisease even in women who received treatment at the age of 55 yrs or younger. The increased rate of dementia was similar between continuous & cyclic treatment
📌 https://www.bmj.com/content/381/bmj-2022-072770

The link between Covid-19 and Alzheimer's disease established

But let’s keep letting it RIP shall we ?

#COVID19 #alzheimersdisease
https://www.news-medical.net/news/20230621/The-link-between-Covid-19-and-Alzheimers-disease-established.aspx

Sometimes it really sucks trying to explain the unexplainable.
#dementia #lewybodydementia #alzheimersdisease #parkinsondisease

“Researchers say that a Colombian man who carried the PSEN1 E280A mutation but also had a rare variant of a brain protein involved in the RELN gene — retained his full cognitive functions until age 67. He eventually developed dementia and died at age 74.” #AlzheimersDisease #alzheimers #dna #isogg #geneadons #mutation https://www.medicalnewstoday.com/articles/rare-genetic-mutation-appears-to-delay-onset-of-early-alzheimers-disease

'For patients in a late-stage trial, the drug called donanemab slowed progression of the disease by 35 per cent compared with those who took the placebo during an 18-month treatment period. The decline in patients’ ability to perform daily tasks was 40 per cent lower for those on the drug.

However, the drug displayed severe side effects such as brain swelling and bleeding and three people on the trial died.'
#alzheimers #alzheimersdisease

https://www.ft.com/content/11a59576-e057-433a-b1f9-393159bda85c

#IDmastodon #Cardiomastodon α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for #COVID19, #HeartFailure, and #alzheimersdisease
📌 https://www.mdpi.com/1422-0067/24/4/4188
📌 https://www.mdpi.com/journal/ijms/special_issues/25601NF5N0

Important commentary by Derek Lowe on the recent results of the analysis of the side effects of anti-amyloid antibodies in Alzheimer patients ⬇️⬇️ #science #alzheimers #alzheimersdisease

Are Anti-Amyloid Antibodes Going to Make Alzheimer's Patients Worse? | Science | AAAS
https://www.science.org/content/blog-post/are-anti-amyloid-antibodes-going-make-alzheimer-s-patients-worse

'Here’s the bottom line from it: “Mild Cognitively Impaired participants treated with anti-Aβ drugs were projected to have a material regression toward brain volumes typical of Alzheimer’s dementia ∼8 months earlier than if they were untreated.” I would say that if someone wants to make the argument that this is of no consequence (or perhaps even beneficial?) that they should step right up and have a crack at it. I (and many others) will watch with great interest. On the other hand, if the way of dealing with these findings is to pretend that they don’t exist, that is really unacceptable.'

#alzheimers #alzheimersdisease #drugdevelopment

https://www.science.org/content/blog-post/are-anti-amyloid-antibodes-going-make-alzheimer-s-patients-worse

🧠 novel therapeutic approach for treating #AlzheimersDisease by utilizing a small peptide derived from the brain peptide p3-Alcβ37.

#AlzheimersDisease #amyloidβ

By Y. Ouchi, T. Suzuki & colleagues, Japan

Read: https://doi.org/10.15252/emmm.202217052

Can a company really predict Alzheimer’s with a 90% accuracy based on your speech?

#AlzheimersDisease #Health

https://www.wired.com/story/wired-health-accexible-speech-biomarkers-alzheimers/

Looking forward to the #adpd23 conference at #gothenburg #sweden. #alzheimersdisease #parkinsonsdisease.

Loss of #METTL3, and the resulting changes in m6A modifications, leads to enhanced #brain infiltration of monocyte-derived #macrophages in a mouse model of #AlzheimersDisease, promoting Aβ clearance and improving pathology & cognitive decline #PLOSBiology https://plos.io/3F1ClcQ

Loss of #METTL3, and the resulting changes in m6A modifications, leads to enhanced #brain infiltration of monocyte-derived #macrophages in a mouse model of #AlzheimersDisease, promoting Aβ clearance and improving pathology & cognitive decline #PLOSBiology https://plos.io/3F1ClcQ