Structures and analysis of three modulators that bind to #AMPAReceptor complexes including the gamma-8 subunit from Ingo Greger's lab.

Nice to see this work that was presented at the #GRC #IonChannels last year coming out, and nice to see proof of @remislp conversion to glutamate.

These compounds were found by functional screening. Considering the heterogeneity of TARP modulation that is now apparent, a strategy of rational design might never have found them.

https://www.nature.com/articles/s41467-023-37259-5