A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.

A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1

https://doi.org/10.1126/science.abj5559

'These data demonstrate an important physiological role of AMPKβ1 Ser108 phosphorylation in promoting fatty acid oxidation, mitochondrial biogenesis and autophagy under conditions of high lipid availability. As both ketogenic diets and intermittent fasting increase circulating free fatty acid levels, AMPK activity, mitochondrial biogenesis, and mitophagy, these data suggest a potential unifying mechanism which may be important in mediating these effects.'

#Metabolism #AMPK

https://www.pnas.org/doi/10.1073/pnas.2119824119

RT @Kei__Sakamoto@twitter.com

Happy to share our latest work demonstrating a key role for a single phosphorylation site on the regulatory beta subunit of #AMPK to stimulate mitochondrial
biogenesis and autophagy with increases in fatty acids.
https://www.pnas.org/doi/10.1073/pnas.2119824119
@PNASNews@twitter.com @Metabolcenter@twitter.com @LabSakamoto@twitter.com

🐦🔗: https://twitter.com/Kei__Sakamoto/status/1594798216461049856