Our favorite Directory image of the week is from Douglas Charney, M.D.
Subspecialty: Medical renal
Diagnosis: Amyloid
See Dr. Charney's Directory profile: https://www.pathologyoutlines.com/directory/douglas-charney

#Directory #profile #medicalrenal #pathology #pathologyoutlines #amyloid #imageoftheweek

Brain cells link amyloid
To early Alzheimer's signs
New hope for prevention

#alzheimers #braincells #amyloid #prevention #haiku #poetry

http://www.medicalnewstoday.com/articles/alzheimers-new-blood-biomarker-could-predict-risk-of-cognitive-decline

#Apolipoprotein E O-glycosylation is associated with #amyloid plaques and #APOE genotype - ScienceDirect - https://www.sciencedirect.com/science/article/abs/pii/S0003269723001215

Referenced link: https://medicalxpress.com/news/2023-03-alzheimer-amyloid-hypothesis-alternative-treatment.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-alzheimer-amyloid-hypothesis-alternative-treatment.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1641830730257891332#m

RT by @physorg_com: Alzheimer's: New study supports #amyloid hypothesis but suggests alternative treatment @columbia @ScienceAdvances https://www.science.org/doi/10.1126/sciadv.add2671 https://medicalxpress.com/news/2023-03-alzheimer-amyloid-hypothesis-alternative-treatment.html

#Astrocytic #APOE4 removal confers cerebrovascular protection despite increased cerebral #amyloid angiopathy - #APOE #cerebrovasculature #astrocyte - https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00610-x

The Knight ADRC and BioFINDER present the most comprehensive look yet at #CSF #tau phosphorylation in #Alzheimer disease. pT217/T217 (%) is better than Aβ42/40 in reflecting #amyloid burden; pT205/T205 better reflects tau. #ENDALZ @WUADRC @biofinder_study

https://www.nature.com/articles/s43587-023-00380-7.epdf?sharing_token=W_CH8jQjdnuvk88is2N9TtRgN0jAjWel9jnR3ZoTv0ObiaG74buAwE2j1o1Jk4wN8rHyjbyAe9Y3RC7LKMKEBGJL6GBW0iphbwpLKOMZfXTbU_J472nJIkS73uFccHkXrHHdGkV6BdpKdbvMjBt2ZL8tBoDcQloX_CROmIoKctlAs4NnADuBnFbygdvzvP8E

Predicting continuous #amyloid #PET values with #CSF and plasma #Aβ42/#Aβ40 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12405

#Amyloid Gains Converts in Debate Over #Alzheimer Treatments https://www.wsj.com/articles/amyloid-gains-converts-in-debate-over-alzheimers-treatments-52b68ee3?mod=hp_listb_pos1

#Plasma #Aβ42/#Aβ40 is a good measure of amyloid status and #CSF Aβ42/Aβ40 is additionally a good measure of total #amyloid burden. #ENDALZ

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12405#.ZADjHPl_cbw.twitter

Our takeaway (as previously for #tau): the field of #amyloid research needs to develop improved model systems, be they in vitro, in cells or in animals, that reproduce the #amyloid structures from human disease. For this, we will need to discover what drives their formation!

Our @biorxivpreprint on the #cryoEM structures of #alphasynuclein #amyloid filaments from a case of jovenile-onset-synucleinopathy is now online in #ActaNeuropathologica. 🥳
https://rdcu.be/c6wAP

Postdoc fellow opportunity in the group of Sheena Radford: https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSAS1057 Advertised as focused on #NMR in context of #amyloid formation. Deadline in March 2023. (Check the link!) #nmrchat

Many #neurological disorders arise from damage to #brain #cells due to a build-up of #misfolded or aggregated #proteins in the brain, like the tau protein and the #amyloid-beta protein.
#Alzheimer #Neuroscience #Biology #sflorg
https://www.sflorg.com/2023/02/ns02022301.html

Important concepts to understand when treating and counseling patients with ATTR-CM.

And nice looking figure @maz_hanna @Ron_Witteles !
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RT @Ron_Witteles
The AVERAGE patient with #ATTR #amyloid cardiomyopathy worsens with time — but there is a spectrum. The evidence is clear: patients are far more likely to improve if they receive #tafamidis.🫀@maz_hanna @KMAlexanderMD @MarthaGrogan1 @MathewMaurer @BrettSperryMD @Paul_P_Cheng https…
https://twitter.com/Ron_Witteles/status/1617595255649599488

Excited to again attend the annual Dutch Huntington research meeting, Monday next week! I guess this is sort of the 2022 version in early 2023 :) Hosted at uniQure in Amsterdam, with many interesting speakers and posters. Come to hear about our ongoing work on figuring out how #polyQ proteins misfold and aggregate, and how we try to prevent and change that bad protein behavior. We are looking forward to see you there! #huntingtondisease #amyloid
More info: http://huntingtonresearch.nl

Working on Covid, Amyloid, or Inflammatory Disease? Maybe on all of them at once? Register for the COVAMINF workshop! Early bird deadline is Jan 31. Luxembourg 15th-16th May 2023 http://covaminf.org . #covid #amyloid #inflammatory

Coming on Thu Feb 2nd: a special online workshop on handling and studying of fibrillar and #amyloid proteins. With presentations by Per Hammarström (Linköping, Sweden), Beat Meier (ETH, Switzerland), Stefano Ricagno (Milan, Italy), Byron Caughey (NIH, USA), and myself (Groningen). Topics: #prion propagation & seeding, structural studies by #ssNMR and #cryoEM, toxicity and biosafety. See #biophysics MOSBRI website: https://www.mosbri.eu/events/workshop-handling-fibrillar-and-amyloid-proteins/

The MOSBRI network (https://www.mosbri.eu ) is a Europe-wide molecular-scale #biophysics research infrastructure network. Biophysics groups at our university (#Groningen) participate with capabilities in single molecule studies, AFM, and #ssNMR: https://www.mosbri.eu/partners/rug-bp/ . Our network offers funds for trans-national access (TNA). So please reach out if you are curious about trying #ssNMR studies of your e.g. protein aggregates, #amyloid or membrane-bound proteins.

#Alzheimers study delves deep into the contested role of #amyloid - https://www.medicalnewstoday.com/articles/if-amyloid-accumulation-is-part-of-normal-aging-what-causes-alzheimers

Unfortunately the CAG repeat GRC coincides with another great meeting: The FASEB Protein Aggregation Conference: Exploring Rugged Landscapes. #amyloid #llps and more! this year in Malahide, Ireland Jun 11-15 https://web.cvent.com/event/720adec4-52f0-4173-ba93-8681b42780eb/summary. #PACSRC