@cellpress TMEM106B is associated with brain aging; myelination disorders; and several neurodegenerative diseases, including #frontotemporallobardegeneration (FTLD), #amyotrophiclateralsclerosis (ALS), #Alzheimersdisease, & #Parkinsonsdisease. Multiple single-nucleotide polymorphisms in TMEM106B have been linked to the severity of these disorders,with an association between risk alleles and increased TMEM106B expression. Different #SARSCoV2 isolates can use TMEM106B for infection

Referenced link: https://medicalxpress.com/news/2023-06-parkinson-disease-drug-ropinirole-safely.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-parkinson-disease-drug-ropinirole-safely.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1664285696520241153#m

RT by @physorg_com: Parkinson's disease drug ropinirole safely slows the progression of #amyotrophiclateralsclerosis, finds clinical trial @CellStemCell https://linkinghub.elsevier.com/retrieve/pii/S1934590923001352 https://medicalxpress.com/news/2023-06-parkinson-disease-drug-ropinirole-safely.html

The FDA has approved Biogen's ALS drug, Tofersen, an antisense oligo targeting SOD1. I wrote about this back in September in my Clinical Pipeline column as part of a shift towards approving drugs based on biomarkers without clear signs of clinical efficacy*.

https://www.nature.com/articles/d41591-022-00098-w

*You can have a look at the trial data in NEJM, in a study that concluded that "In persons with SOD1 ALS, tofersen reduced concentrations of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks but did not improve clinical end points and was associated with adverse events."

https://lnkd.in/dwGMYGgh

#NatureMedicine #amyotrophiclateralsclerosis #drugdevelopment #pharma

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://plos.io/3LB8ITH