#Aneuploidies are an ancestral feature of #trypanosomatids, and an ancient chromosome #duplication is maintained in extant species

João Luís Reis-Cunha et al
bioRxiv 2023.06.26.546280; doi: https://doi.org/10.1101/2023.06.26.546280

#leishmania #genome #genomics #aneuploidy

Effects of #Aneuploidy on cell behavior & function

Cause:
ROS
DNA replication
mitosis
mechanical confinement

Direct dosage + secondary Effect:
Redox, bioenergetic, proteostasis, Osmosis
Cancer, Aging

Dr Rong Li & Jin Zhu Nature Reviews MCB 2023
https://www.nature.com/articles/s41580-021-00436-9

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Any evidence on #Aneuploidy in cardiovascular biology?

From Abraham Aviv lab @ATHjournal 2001

Age-dependent aneuploidy & telomere length of the human vascular endothelium
https://www.atherosclerosis-journal.com/article/S0021-9150(01)00506-8/fulltext

Tetrasomy Chr6 Chr16
Loss ChrY

Aneuploidy in cardiovascular diseases?🧐

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Mice with #SpindleAssemblyCheckpoint protein BubR1 deficiency have a spectrum of vascular defects

Vascular BubR1 1/3

Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1

Dr. Jan van Deursen lab @StrokeAHA_ASA 2007
https://www.ahajournals.org/doi/10.1161/01.STR.0000257967.86132.01

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Vascular BubR1 2/3

BubR1 Insufficiency Inhibits #NeointimalHyperplasia Through Impaired Vascular #SmoothMuscleCell Proliferation in Mice

Dr. Takuya Matsumoto lab @atvbahajournals 2014
https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304737
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Vascular BubR1 3/3

BubR1 insufficiency impairs #Angiogenesis in aging and in experimental critical limb ischemic mice

Dr. Takuya Matsumoto lab @JVascSurg 2018
https://www.jvascsurg.org/article/S0741-5214(17)32041-4/fulltext

How do #yeast adapt to #chromatinization with human #histones and subsequent #aneuploidy?

Jeff Boeke, @maxhaase et al from NYU Langone find #ploidy stabilization by DASH/Dam1 complex mutants that weaken #kinetochore-#microtubule attachment strength

https://www.embopress.org/doi/10.15252/embj.2022112600

Enjoying this paper from the Sheltzer lab - it reads a bit like a group of biologists playing detective. They start with a theory that #aneuploidy is necessary for the malignancy of some cancer lines, and then trace this all the way to showing some very tight links to MDM4. They even propose a therapeutic using differential sensitivity between disomic and trisomic cells.

https://www.biorxiv.org/content/10.1101/2023.01.09.523344v1

At #SMBE #GS6 - good poster session, including models of #aneuploidy stress responses in yeast that link to the architecture of #PPI #networks (relative rate of direct vs indirect PPI connections)