@medrxivpreprint
The commonly used #antibiotics #amoxicillin, #metronidazole, #piperacillin-tazobactam & #Clindamycin reached levels equivalent to blood within infected pleural fluid.Low penetration of trimethoprim into the pleural space raised concerns about the use of #cotrimoxazole for patients with #Pleuralinfection or parapneumonic effusions.
#Antibiotic #pharmacokinetics in infected #pleuraleffusions
https://www.medrxiv.org/content/10.1101/2023.09.08.23295282v1.full.pdf

This is interesting - providing individualised antibiotic plans safely reduces #carbapenem prescriptions.

But isn't this just what happens in specialties, like #hematology or #intensivecare, that get regular #microbiology / #infectiousdisease #MDT review of their #antibiotic prescriptions?
#IDmastodon #medicine #oncology #orthopedics #ICU #AMR #pediatrics #criticalcare
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad518/7255898?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=cid&utm_medium=email

We may be losing #cefiderocol far sooner than we hoped.

Timely meta-analysis. Look at those #resistance rates in #carbapenem resistant Enterobacterales!

#microbiology #AMR #antibiotics #antibiotic #CriticalCare #Pseudomonas #Acenitobacter #infectiousdiseases #IDMastodon #medicine

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00413-5/fulltext?dgcid=raven_jbs_aip_email

What? Chemist doesn't have antibiotic pills and provides a powder to be dissolved in water? I've never heard of such a thing #Dublin #Hickeys #antibiotic #powder

A very interesting resource at first glance.

"Antimicrobial use in Residential Care Facilities and Nursing Homes" - HSE.ie

https://www.hse.ie/eng/services/list/2/gp/antibiotic-prescribing/prescribing-ltcf/

#MedMastodon #antibiotic #prescribing

We commonly use #nitrofurantoin to treat #UTI and even sometimes as prophylaxis for recurrent infections.

Super safe #antibiotic but a reminder that rarely it can cause serious complications #lung #fibrosis
@infectiousdiseases @microbiology #IDMastodon #MedMastodon #medicine

Chronic Nitrofurantoin-Induced Lung Injury

https://www.nejm.org/doi/full/10.1056/NEJMicm2214831

Important reminder that quantifying prevalence of #AMR at population level does not predict well the risk of #antibiotic resistance at individual patient level
👏 @EliP
#IDMastodon #infectiousdiseases #microbiology
@infectiousdiseases @microbiology @MicrobioJC #PersonalizedMedicine #personalisedmedicine
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad467/7240295?searchresult=1

#IDmastodon @idsainfo #Antibiotic prescribing was high and with little or no decline following #SARSCoV2 diagnosis but was reduced in #COVID19–vaccinated individuals, highlighting the importance of vaccination and antibiotic stewardship in older adults with #COVID19 .
https://academic.oup.com/cid/article/77/3/362/7097498

The pandemic, backtracking by some large producers on antibiotic use in farming, increased number of immunocompromised folks, slow to nonexistent drug pipeline... we're in trouble when it comes to #antibiotic #resistance. https://www.usatoday.com/story/news/health/2023/07/30/risk-of-antibiotic-resistant-bacteria/70420036007/

Gizmodo: UK Man Gets Gnarly, Newly Discovered Infection From Stray Cat Bite https://gizmodo.com/uk-newly-discovered-infection-from-stray-cat-bite-1850692665 #entertainmentculture #healthmedicalpharma #infectiousdiseases #bacteriology #animalbites #antibiotic #infection #injuries #bacteria #zoonoses #zoonosis #catbite #wound #cat

#KnowledgeByte: #Antibiotic #Resistance is a serious public health problem.

Antibiotic resistance is increasing globally due to increased prescription and dispensing of antibiotic drugs in many countries.

https://knowledgezone.co.in/trends/explorer?topic=Antibiotic-Resistance

#QuizOfTheDay: Penicillin, the first true #Antibiotic, was discovered in 1928.

Who discovered #Penicillin?

A. Alexander Fleming
B. Louis Pasteur
C. Edward Jenner
D. Robert Koch

https://knowledgezone.co.in/resources/quiz?qId=5f68a469adb45455801ab267

#Antibiotic-resistant #bacteria found in Canterbury #cockles and #watercress.

https://phys.org/news/2023-07-antibiotic-resistant-bacteria-canterbury-cockles-watercress.html

Financial #incentives for drug development should be redesigned.

Example 1: "there is little financial incentive for drug companies to develop new antibiotics": https://archive.is/iid01

Example 2: "Pfizer sold $37.8 billion of its Covid vaccine last year": https://www.cnbc.com/2023/01/31/the-covid-pandemic-drives-pfizers-2022-revenue-to-a-record-100-billion.html

Wouldn't it make more sense to publicly buy out drugs? What's the right price to pay, and place a #covid #vaccine or a new #antibiotic in the public domain? What are the counter arguments to this approach?

#Gene-Swapping #Viruses Are Likely Behind #Antibiotic Resistance, Study Finds
https://www.inverse.com/science/gene-swapping-viruses-are-helping-bacteria-become-antibiotic-resistant

🇺🇦 Ukraine war victims: The unexpectedly high levels of resistance in #Klebsiella pneumoniae are a cause for great worry

📌 Scientists from Lund University in Sweden collaborated with microbiologists in Ukraine to investigate bacterial resistance in war-wounded patients treated in hospitals. The findings indicate that a significant number of patients were afflicted with bacteria displaying an exceptionally high level of #antibiotic #resistance.

http://outbreaknewstoday.com/ukraine-war-victims-the-unexpectedly-high-levels-of-resistance-in-klebsiella-pneumoniae-are-a-cause-for-great-worry-42841/

https://zeolite.reviews/zeolite-av/ Nature’s Natural Antiviral, Cancer Relief and Antibiotic. Natural Zeolite-AV (Antiviral and Anti-Cancer) is a natural antiviral mineral that boost your immunity against virus infections like the flu (or covid-19 and variants with graphene oxide.) Zeolite AV is one of the few things that are true antidotes to the graphene oxide, spike proteins, heavy metals, toxins and microbials (viruses) that really works. It's proven in the PubMedgov site to do so. Masks don't help they actually keep toxins in your body and incubate them creating antibiotic resistant and antiviral resistant infections! #cancer #antiviral #zeolite #virus #antibiotic

Three #UK #supermarkets sell #antibiotic dosed chickens linked to deadly #superbug outbreak
https://www.itv.com/news/2023-06-20/uk-supermarkets-sell-antibiotic-dosed-chickens-linked-to-deadly-superbug
#Sustainability #Health #FoodSafety

In a paper now out in Angewandte, we have applied directed evolution on the nonribosomal peptide synthetase (#NRPS) making the peptide #antibiotic gramicidin S. Just a few mutations were sufficient to make the NRPS incorporate the non-standard building block piperazic acid instead of proline into the peptide. Directed evolution of NRPSs is needed to adapt the structures of antibiotic peptides to help fight increasing #AntimicrobialResistance.

https://doi.org/10.1002/anie.202304843

@LeibnizHKI

AI Versus #Antibiotic Resistance
https://medium.proto.life/ai-versus-antibiotic-resistance-66e9ebfb0640
#AI can help overcome both #scientific and #financial hurdles to tackle this serious threat to global #health.