Gladwyn d’Souza · @godsouza
177 followers · 3180 posts · Server sfba.social
TrangAston :verified: · @CastlTrAstonDrs
1450 followers · 3209 posts · Server med-mastodon.com

@medrxivpreprint
The commonly used , , -tazobactam & reached levels equivalent to blood within infected pleural fluid.Low penetration of trimethoprim into the pleural space raised concerns about the use of for patients with or parapneumonic effusions.
in infected
medrxiv.org/content/10.1101/20

#antibiotics #Amoxicillin #metronidazole #piperacillin #clindamycin #cotrimoxazole #pleuralinfection #antibiotic #pharmacokinetics #pleuraleffusions

Last updated 1 year ago

Gabriele Pollara · @gpollara
1084 followers · 3844 posts · Server med-mastodon.com

Linezolid probably a bit safer than we think & probably can give >4 weeks with close observation.

Great drug, it's oral, but still makes me a bit apprehensive about using it for a long course, certainly at 600mg BD.

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects | Journal of Antimicrobial Chemotherapy | Oxford Academic academic.oup.com/jac/advance-a

#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #medicine #linezolid

Last updated 1 year ago

Gabriele Pollara · @gpollara
1084 followers · 3844 posts · Server med-mastodon.com

Reminder to pick your outcomes.

Vancomycin vs Fidaxomicin in - same mortality, but lower recurrence with fidaxo

The Effect of Antibiotic Therapy for Clostridioides difficile Infection on Mortality and Other Patient-Relevant Outcomes: a Systematic Review and Meta-analysis - Clinical Microbiology and Infection clinicalmicrobiologyandinfecti

#Cdiff #clostridiumdifficile #antibiotics #microbiology #IDMastodon #infectiousdeseases

Last updated 1 year ago

Valfaris · @Ananke
3 followers · 17 posts · Server freie-re.de

Was ist eigentlich mit MRSA (Methicillin-resistant Staphylococcus aureus - ein Bacterium das multiresistent gegen viele Antibiotika ist)? Und wie sieht es bzgl. Neu- und Weiterentwicklung von Antibiotika aus?

cdc.gov/mrsa/healthcare/index.

#mrsa #antibiotics #bacteria #cdc #healthcare

Last updated 1 year ago

Kriszta Satori · @fulelo
5894 followers · 6027 posts · Server journa.host
Gabriele Pollara · @gpollara
1082 followers · 3765 posts · Server med-mastodon.com
neat_news · @neat_news
6 followers · 244 posts · Server federated.press

By extensively using mutations, researchers tested a full range of variants of antibiotics to find the ones that are most effective in attacking some bacteria. This way new antibiotics may be developed to treat infections that are resistant to existing antibiotics. See neat-news.com/2023/09/244.php.

#antibiotics #resistance

Last updated 1 year ago

Gabriele Pollara · @gpollara
1076 followers · 3742 posts · Server med-mastodon.com
Gabriele Pollara · @gpollara
1077 followers · 3699 posts · Server med-mastodon.com

This is intriguing: phage therapy induces bacterial resistance but also reduced virulence.

So clinical benefit post-phage could also stem from bacterial attenuation rather than just eradication.

Question is how sustainable this effect may be.

clinicalmicrobiologyandinfecti

#phages #bacteria #microbiology #IDMastodon #medicine #MedMastodon #AMR #antibiotics #bacteriophage

Last updated 1 year ago

Oden · @Gjallarhornet
1059 followers · 9378 posts · Server mastodon.nu
Gabriele Pollara · @gpollara
1076 followers · 3696 posts · Server med-mastodon.com
Stephan Hacker · @Stephanhacker2
273 followers · 214 posts · Server mstdn.science

Great talk by Kevin Neumann at . He talked about his group's work on zitterionic polymers as coatings to prevent bacterial biofilms. Exciting chemistry of stable ylides to have a minimal distance between positive and negative charge. doi.org/10.1002/anie.202308971

#iupacchains2023 #chemistry #chemiverse #polymers #antibiotics

Last updated 1 year ago

Stephan Hacker · @Stephanhacker2
272 followers · 207 posts · Server mstdn.science

Interesting talk by Marko Radojković from the Leiden Insitute of Chemistry in the "Antibiotics and Antivirals" session of . He talked about his research on better understanding enzyme evolution on the example of the β-lactamase BlaC.

#iupacchains2023 #chemistry #chemiverse #antibiotics

Last updated 1 year ago

Gabriele Pollara · @gpollara
1055 followers · 3569 posts · Server med-mastodon.com
Thiago Carvalho · @cyrilpedia
1892 followers · 10900 posts · Server qoto.org

"On Tuesday, an international team announced in the journal Cell that they had identified a potential new antibiotic lurking unnoticed in the sandy soil of North Carolina. The compound, called clovibactin, employs an unusual method of killing bacteria that makes it tough for targets to develop resistance. While clinical trials in humans are several years away, the finding is a glimmer of hope in an increasingly drug-resistant world."

ft.com/content/a8d62524-3f3f-4

#antibioticresistance #microbiology #antibiotics #drugdevelopment

Last updated 1 year ago

Feargal Ryan :rna: · @feargal
317 followers · 256 posts · Server genomic.social

An antibiotic from an uncultured bacterium binds to an immutable target | Cell

New antibiotic dropped.

"we report the discovery of clovibactin.... efficiently kills drug-resistant Gram-positive bacterial pathogens without detectable resistance"

cell.com/cell/fulltext/S0092-8

#microbiology #antibiotics

Last updated 1 year ago

Axel Visel · @AxelVisel
463 followers · 119 posts · Server genomic.social

Katherine Duncan from Strathclyde University:

Linking genes and metabolites for informed antibiotic discovery

@LBNLBioSci

#jgi2023 #actinomycetes #streptomyces #antibiotics #JGI

Last updated 1 year ago