Come and get it! If you can afford it 🤬

The #COVID #XBB #variant family #booster approved in the #US for everyone older than 5 and will start being available by the end of this week. Price will be an obscene $100 per dose.

#Health "#insurance" *should* cover the cost, in-network, but we know how insurance finds ways to not ensure our health.

Good news is "It is likely that the XBB.1.5 #monovalent #vaccines will raise #antibodies against all the circulating variants"
https://www.nbcnews.com/health/health-news/fda-clears-new-covid-boosters-5-things-know-rcna102577

SBGrid's eLife paper was cited by SBGrid member M. Gordon Joyce U.S. Military HIV Research Program in Journal of Virology.

Read more at: Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity

https://journals.asm.org/doi/full/10.1128/jvi.01596-22?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=457&lea=24537&ctr=0&par=1&trk=a0N3s00000PtIByEAN

<ALT= Crystal structure and epitope analysis of the SARS-CoV-2 RBD with WRAIR-2063 Fab>

#Science #virology #antibodies #SBGrid

Dr Ruth Crystal September 2, 2023 COVID Newsletter

"BA.2.86

Yunlong Cao reported that BA.2.86 can evade our neutralizing #antibodies, even if we had prior XBB.1.5 #infections, meaning that the new fall #vaccine may not protect well against BA. 2.86. But there is a caveat. It turns out that BA.2.86 can evade antibodies, but it is not as infectious or transmissible as other variants in circulation now.

This is reassuring. We know that antibodies from the new Fall XBB.1.5 vaccine expected out in about 2 weeks, will protect us from EG.5 and FL.1.5.1 variants which are in circulation now in the U.S. and many parts of the world.

Ben Murrell’s lab in Sweden announced that eight out of twelve blood donors with prior XBB.1.5 infection had antibodies that could neutralize BA.2.86. The updated fall booster against XBB.1.5 may provide some protection against BA.2.86. We will have to wait and see"

#Covid

https://drruth.substack.com/p/covid-news-and-more-9223

1/n

#Covid19 #antibodies may give us partial #immunity to #SARS and #MERS
https://www.newscientist.com/article/2387196-covid-19-antibodies-may-give-us-partial-immunity-to-sars-and-mers/?amp;utm_source=NSNS&amp;utm_medium=RSS&amp;utm_content=news

“We have not seen a new #variant with this many new #spike mutations happening all at once since the emergence of the original #Omicron,” Bloom told NBC News. “Based on the sequence, I think we can be very confident this [variant] is going to be relatively good at evading the #antibodies that most people have from prior #infections and #vaccinations.” https://universeodon.com/@popsci/110929263757878504

Drugs
Producing fast, unseen
Machines making artisinal
Aired molecules found in a breeze
AI-driven

#ai #drugdiscovery #antibodies #automation #cinquain #poetry

https://www.wired.com/story/labgenius-antibody-factory-machine-learning/

Move over IgG: WTA-specific IgM is unexpectedly good at targeting Staphylococcus aureus. 🦠

Insightful and entertaining preLight prepared by Lucy Bowden #BYU covering work from the #vanSorgeLab that could inspire new antibody-based therapies & vaccines. #preprint

#preLight 👉 https://prelights.biologists.com/highlights/glycan-specific-igm-is-critical-for-human-immunity-to-staphylococcus-aureus-v2/

#antibodies #staphylococcus #microbiology #immunology #therapy #vaccines

Initial findings from a large clinical trial testing a vaccine against the chikungunya virus show the vaccine generates protective antibodies in the vast majority of recipients.

https://sciencebusiness.technewslit.com/?p=45079

#News #Press #Science #Business #Biotechnology #Chikungunya #Virus #Mosquitoes #Fever #ClinicalTrial #Antibodies #Placebo #AdverseEffects #Efficacy #Denmark

Scientists discover 'variant-proof' antibodies that can neutralize every strain of #Covid - as virus rates tick up across US amid late summer wave.

The newly found E7 antibody works against even newest Omicron sub-variants. The new findings bring hope that a universal coronavirus vaccine is achievable.

#COVID19 #SarsCov2 #antibodies #CovidResearch #vaccine #Omicron #CovidVaccine

https://www.dailymail.co.uk/sciencetech/article-12356917/Scientists-discover-variant-proof-antibodies-neutralize-strain-Covid-virus-rates-tick-amid-late-summer-wave.html

Meharry Medical College graduate student KeAndreya Morrison highlighted a Cell Reports publication with contributions from SBGrid member Peter Kwong of the National Institute of Allergy and Infectious Diseases (NIAID) in which the authors describe improved HIV neutralizing antibodies using OSPREY, an open-source protein design software.

https://www.tumblr.com/sbgridconsortium/724367027985416192/a-new-method-for-hiv-antibody-design

#science #SBGrid #antibodies #cryoem #research

<ALT= Cyro-EM structure of PG9RSH Y(100k)D variant>

New research finds that breast milk contains for each mother a stable set of antibodies across pregnancies. The fact helps to explain why some babies are protected against some diseases, such as necrotizing enterocolitis, and others not. See http://www.neat-news.com/2023/07/201.php. #breast_milk #antibodies

#IDMastodon #Immunology #Viralimmunology @JCI_insight Although #PublicHealth cautionary measures have relaxed with the passage of time and improvements in treatment, #SARSCoV2 remains a potentially lethal threat, especially to those who are #immunocompromised. The ability to rapidly screen a library of #antibodies for maintained or reduced efficacy upon identification of a new strain, or the ability to select efficacious antibodies upon sequencing a patient’s infecting virus, may be invaluable.

#Antibodies that attack the body’s own brain or nerve tissue can trigger #autoimmune diseases of the #nervous system such as #dementia, #epilepsy and #psychosis.

BecauseY, a new Clinical Research Unit at #CharitéBerlin, aims to learn more about the disease mechanisms, diagnosis, and ways to treat these neurological disorders. It is receiving funding from @dfg_public. Congratulations & good luck to the team!

👉
https://www.charite.de/en/service/press_reports/artikel/detail/new_center_to_spotlight_neurological_autoimmune_disorders/

#CharitéNeuro #Medicine #Science #FutureMedicine #Research

@Nature The safest strategy for #COVID19 & other variable 🦠 is to use combinations of #antibodies. It would be even better to use combinations of multispecific antibodies that recognize antigenic regions under minimal immune pressure, because those are the regions that are least likely to mutate .the perspectives view of the Drug maker - Laura Walker
https://www.nature.com/articles/d41586-023-02125-3?utm_medium=Social&utm_campaign=nature&utm_source=Twitter#Echobox=1688041689

#IDMastodon #Viralimmunology Individuals with a history of #COVID19 produced twice as many #antibodies than vaccinated individuals without prior #SARSCoV2 infection, with an exponential increase observed in just 6 days.

More infectious #XBB116 #Arcturus #COVIDvariant can resist #antibodies
https://newstarget.com/2023-06-23-arcturus-strain-resists-covid-antibodies-spreads-rapidly.html

More infectious #XBB116 #Arcturus #COVIDvariant can resist #antibodies

https://www.naturalnews.com/2023-06-23-arcturus-strain-resists-covid-antibodies-spreads-rapidly.html

Nearly All #Americans Had #Covid-19 #Antibodies Last Fall — Here’s What That Means For Next Year
https://www.inverse.com/health/nearly-all-americans-had-covid-19-antibodies-last-fall

SBGrid's eLife paper received a new citation in the month of May from #SBGrid member Jean-Philippe Julien from Hospital for Sick Children Research in a new paper in Science Translational Medicine: A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.

https://www.science.org/doi/full/10.1126/scitranslmed.adf4549?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=453&lea=24537&ctr=0&par=1&trk=a0N3s00000R9zAaEAJ

#SBGrid
#Science
#Antibodies
#viruses

"Researchers are now looking for the holy grail of #antibodies, one that would be longer-lasting and effective across many variants of #SARSCoV2, including those that might emerge in the future." #Covid19

A Crucial Group of #Covid Drugs Has Stopped Working | WIRED
https://www.wired.com/story/a-crucial-group-of-covid-drugs-has-stopped-working/?mbid=social_twitter&utm_brand=wired&utm_campaign=falcon_y0pL&utm_medium=social&utm_social-type=owned&utm_source=twitter