The emergence of new #antigen #branches of #H9N2 avian #influenza virus in #China due to antigenic drift on #hemagglutinin through #antibody escape at immunodominant sites, Emerg Microbes Infect., https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2246582 #science #research #zoonoses #panzootic #epizootic #enzootic #pandemic

"#COVID Testing.

If you get a negative…

False negatives at the beginning of infection are very common, thanks to the virus mutating. In a recent study, #antigen & #PCR tests only agreed 47-58% of the time. If they did agree, there was a 1-8 day delay between a PCR turning positive & an antigen test turning positive.

The higher we are in a wave, the more skeptical you should be of a negative result. There are 2 things you can do to help reduce false negatives

Swab throat & salvia. These are positive days before the nose.

Repeat testing. 2 tests within 48 hours catch 92% of #symptomatic cases & 39% of #asymptomatic cases. 3 tests 48 hours apart detected 94% of symptomatic & 57% of asymptomatic patients.

If you get a positive…
Positives are positives. You’re infectious.

The faintness of a line provides clues, though:

Very bold line= you’re very contagious.

Barely see the line= you’re at the beginning or the end of your infection window."

https://yourlocalepidemiologist.substack.com/p/riding-the-covid-19-waves-2023-style

1/n

When to test for #COVID

"People often have questions regarding home rapid #antigen Covid tests. A new study shows that if someone is exposed to Covid but they do not have symptoms, they should do a rapid antigen test three times at 48 hour intervals (i.e. day 1, 3, 5) in order to rule out a COVID infection. But, if someone has Covid symptoms after an exposure, they should do a rapid antigen home test two times separated by 48 hours (i.e. day 1 and day 3) in order to rule out being infected."

https://www.acpjournals.org/doi/10.7326/M23-0385

Source:https://drruth.substack.com/p/covid-news-and-more-71523

''ZPIV to b well tolerated in #flavivirus naive & primed adults but that immunogenicity varied significantly according 2 antecedent flavivirus #vaccination status. Immune #bias towards flavivirus #antigen of initial exposure & timing of vaccination may have impacted responses. A 3rd ZPIV dose overcame much, but not all, of discrepancy in immunogenicity. Results of this phase 1 clin trial have implications for further evaluation of ZPIV's imunisation schedule & use of concomitant vaccinations.''

Scientists use sound waves to test how well synthetic #antibodies bind to their #antigen targets.

https://phys.org/news/2023-06-scientists-synthetic-antibodies-antigen.html

#Statement on the #antigen composition of #COVID-19 #vaccines, https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines

RT @Eurosurveillanc: Our new issue is available
⬇️⬇️
https://bit.ly/EUS2816

Topics include
#SARSCoV2 #minks #COVID19 #Omicron
#CCHF #hemorrhagicfever #CrimeanCongo
#outbreaks #antigen #publichealth #IDTwitter

🐦🔗: https://n.respublicae.eu/ECDC_EU/status/1649065798269390850

Murine #COVID19 #lethality is characterized by #lymphoid depletion associated with suppressed #antigen presenting cell functionality https://ajp.amjpathol.org/article/S0002-9440(23)00119-0/fulltext?rss=yes

DNA sensing via the #cGAS/STING pathway regulates #immunoproteasome function and #MHC class I #antigen presentation to promote #Tcell activation - with implications for the pathology of idiopathic pulmonary fibrosis

Silke Meiners et al ForschungszentrumBorstel@norden.social

https://www.embopress.org/doi/10.15252/embj.2022110597

@acepinecone

Do you mean the exhaustion valve?

those #respirators are safe for the #dentist but not for patients

KN99 & #ARANET4 should be standard

airfilters & open windows, too

every #patient should be tested for #sourcecontrol with calibrated #antigen #SarsCoV2 tests

#CovidIsNotOver
#COVIDisAirborne

#servicetoot

Hi, is anyone using #asdf with #antigen ? If so, do you use a bundle to autoconfigure ?

#Linux #programming #zsh #shell #scripting

#Scientists at St. Jude Children’s Research Hospital added a #molecular anchor to #chimeric #antigen #receptors (#CARs), increasing the anti-cancer activity of cellular #immunotherapies in #cancer models.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02052305.html

[Correspondence] #BNT162b2 #antigen dose and #SARS-CoV-2 #omicron infection in #adolescents https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00005-1/fulltext?rss=yes

My friends in #Japan, do you have any recommendation for #antigen test kits available online that are:

a) not crazy expensive and
b) up to date with new variants (or doesn’t that matter?)

Thanks!

#Covid
(@pippa could you boost to famichiki? Thanks!!!)

Heute wieder im Krankenhaus. Mit der Notwendigkeit eines Antigen-Tests, den man nicht in der Klinik machen kann, sondern 300 Meter weiter beim Testzentrum auf dem Lidl-Parkplatz, wo es vom Klinikum aus nicht mal einen Fußgänger-Überweg über die Kreuzung gibt! 🤦🏼‍♂️ #krankenhaus #prozessefuerdietonne #kompliziert #wassolldas #covid #antigen

Phylogenetic data via #Nextstrain shows that the surge was in part due to #Omicron overtaking #Delta. Relatively speaking, #XBB is still comparatively new and it may take a minute to see how fast it spreads.

It's really 🤬 frustrating that we don't have decent case count data because of almost exclusive use of #antigen tests and no routinized roll-out of Ag test reporting. We're 3 years in, we should be hurling resources at this thing like nothing else.

In case you were wondering, the acronym RAT stands for "Rarely Accurate Test."

#Covid #Antigen #Testing

RT @SciImmunology@twitter.com

A 2021 study from @DanaFarber@twitter.com @broadinstitute@twitter.com scientists yielded a new high-throughput screening methodology to identify specific #antigen parts, or epitopes, among peptide pools—akin to finding needles in a haystack. https://scim.ag/15O @meyersonlab@twitter.com @mnleeee@twitter.com

🐦🔗: https://twitter.com/SciImmunology/status/1612177352385085447

Maxime Dernier n'est pas content que Peepee lui ait volé des fidèles l'an dernier
😂

RT @ppc_westisland@twitter.com

Chef de l'opposition officielle à Ottawa, Pierre Poilievre @PierrePoilievre@twitter.com, croit toujours que les tests rapides #antigen et les #VaccinsCovid sont fiables et devraient être imposés aux gens! Vous pensez encore que le @CPC_HQ@twitter.com va mettre fin à cette folie après près de 3 ans? 🤔

🐦🔗: https://twitter.com/ppc_westisland/status/1608943128115044353

SciShow
The 1918 Pandemic Never Ended
https://www.youtube.com/watch?v=9HbuE_fQctg

#SciShow #Antigen #AntigenicDrift #AntigenicShift #Flu #H1N1 #H2N2 #H3N2 #H5N1 #Influenza #OriginalAntigenicSin #Pandemic #Symptom #Y1918 #Y1957 #Y1968 #Y2009 #Zoonotic