New preprint from our lab. We report that genomic islands containing Gamma-Mobile-Trio proteins are bacterial armories stockpiled with antibacterial, anti-phage, and anti-eukaryotic weapons.
This one has something for everybody: #antiphage #T6SS #Vibrio #MGE
https://www.biorxiv.org/content/10.1101/2023.03.28.534373v2
An E1–E2 fusion protein primes #antiviral immune signalling in bacteria | Nature
#Bacteriophages inhibit and evade cGAS-like immune function in bacteria: Cell
#phage #antiphage #signaling
https://www.cell.com/cell/fulltext/S0092-8674(22)01584-7
#signaling #antiphage #phage #bacteriophages
A conserved family of immune effectors cleaves cellular ATP upon #viral infection |
Synergy and regulation of #antiphage systems: toward the existence of a bacterial immune system? -
#phage #phages
https://www.sciencedirect.com/science/article/abs/pii/S1369527422001229
Antiphage small molecules produced by #bacteria – beyond protein-mediated #defenses: Trends in #Microbiology
#phage #phages #antiphage @ael_hardy
#antiphage #Phages #phage #microbiology #defenses #bacteria
Antiviral signaling by a cyclic nucleotide activated CRISPR protease
https://www.nature.com/articles/s41586-022-05571-7
#phage #bacteria #immunesystem #antiphage #crispr
#crispr #antiphage #immunesystem #bacteria #phage
Antiviral signaling by a cyclic nucleotide activated #CRISPR protease
#phage #signaling #antiphage #crispr
Our initial census of #antiphage systems in genomes revealed that on average bacteria encode at least 6 anti-phage mechanisms. This paves the way for many interactions between systems.
So we decided to review the existing litterature about #synergy and #regulation of #antiphage systems.
Already cool stuff and clearly a lot more to discover :). Hopefully, this can help to think about how multiple systems coexist in a cell !
https://www.sciencedirect.com/science/article/pii/S1369527422001229
#antiphage #synergy #regulation