Molecular #mechanisms of #SARS-CoV-2 #resistance to #nirmatrelvir, Nature: https://www.nature.com/articles/s41586-023-06609-0 #research #antivirals #covid19 #drugs #mutations #mpro #protease
#mechanisms #sars #resistance #nirmatrelvir #research #antivirals #COVID19 #drugs #mutations #mpro #protease
Multicenter, randomized controlled, open label evaluation of the #efficacy and #safety of #arbidol hydrochloride tablets in the #treatment of #ILI cases, BMC Infect Dis.: https://doi.org/10.1186/s12879-023-08570-9 #influenza #research #medicine #drugs #antivirals #oseltamivir
#efficacy #safety #arbidol #Treatment #ili #influenza #research #medicine #drugs #antivirals #oseltamivir
Amazing talk by Seino Jongkees in the "Antibiotics and Antivirals" session of #IUPACCHAINS2023. He talked about his group's work on the RaPID platform to identify antiviral cyclic peptides. Exciting applications to influenza and #SARSCoV2 surface proteins. #Chemistry #ChemiVerse #Antivirals #Peptides https://doi.org/10.1021/acschembio.2c00040
#iupacchains2023 #SarsCoV2 #chemistry #chemiverse #antivirals #peptides
I tested #positive yesterday. I had a scratchy #Throat and a slight #cough so I went to #CityMD. I’ve taken two doses of #Paxlovid so far, and my symptoms remain mild. In fact, the #aftertaste of the #antivirals is worse than the COVID symptoms. There goes our #wine #cruise on the #hudsonriver on #saturday.
#positive #throat #cough #citymd #paxlovid #aftertaste #antivirals #wine #cruise #hudsonriver #saturday
Cox, R.M., Lieber, C.M., Wolf, J.D. et al. Comparing #molnupiravir and #nirmatrelvir/ritonavir #efficacy and the effects on #SARS-CoV-2 #transmission in animal #models. Nat Commun 14, 4731 (2023). https://doi.org/10.1038/s41467-023-40556-8 #research #science #antivirals #prophylaxis
#molnupiravir #nirmatrelvir #efficacy #sars #transmission #models #research #Science #antivirals #prophylaxis
In vitro and in vivo characterization of #SARS-CoV-2 #resistance to #ensitrelvir https://www.nature.com/articles/s41467-023-40018-1 #antivirals #research #science #pharmacology
#sars #resistance #ensitrelvir #antivirals #research #Science #pharmacology
#Coronavirus Disease Research #References (by AMEDEO, June 30 ’23),
https://etidioh.wordpress.com/2023/06/30/coronavirus-disease-research-references-by-amedeo-june-30-23/ #epidemic #pandemic #antivirals #vaccines #library #medicine
#Coronavirus #references #epidemic #pandemic #antivirals #vaccines #library #medicine
#AI can suggest #Covid19 #antivirals from #proteinsequence alone
https://www.chemistryworld.com/news/ai-can-suggest-covid-19-antivirals-from-protein-sequence-alone/4017651.article
#ai #COVID19 #antivirals #proteinsequence
The combined #effect of #oseltamivir and #favipiravir on #influenza a virus #evolution in patients hospitalized with severe influenza, Antiviral Res.: https://doi.org/10.1016/j.antiviral.2023.105657 #antivirals #mutations #HA #NA #treatment
#effect #oseltamivir #favipiravir #influenza #evolution #antivirals #mutations #Ha #na #Treatment
[Articles] Intravenous #aviptadil and #remdesivir for #treatment of #COVID19-associated hypoxaemic respiratory failure in the #USA (TESICO): a randomised, placebo-controlled trial https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00147-9/fulltext?rss=yes #antivirals #medicine
#aviptadil #Remdesivir #Treatment #COVID19 #usa #antivirals #medicine
I've been taking #Paxlovid #antivirals to treat #COVID19Aus for 3 days now and had constant #nausea #diarrhoea and #metallicmouth. Also, I am experiencing #agitation and #sleepdeprivation to the point where I feel I must stop as it's affecting my quality of life. (Not against #antivirals at all, but maybe they're not for me.) #Australia :nkoSleep:
#Australia #sleepdeprivation #agitation #metallicmouth #diarrhoea #nausea #COVID19Aus #antivirals #Paxlovid
I've been taking #Paxlovid #antivirals to treat #COVID19Aus for 3 days now and had constant #nausea #diarrhoea and #metallicmouth. Also, I am experiencing #agitation and #sleepdeprivation to the point where I feel I must stop as it's affecting my quality of life. (Not against #antivirals at all, but maybe they're not for me.) #Australia :nkoSleep:
#Australia #sleepdeprivation #agitation #metallicmouth #diarrhoea #nausea #COVID19Aus #antivirals #Paxlovid
COVID patients living in Hong Kong nursing homes given oral #antivirals reduced their hospitalization risk by A LOT. Interestingly, #molnupiravir performed better in this study than others. Dr. Griffin surmised it was probably because you could get a faster #COVID diagnosis and treatment in a nursing home. (Like all antivirals, you shouldn’t wait to get it, you should take it as soon as you can.) 10/
#antivirals #molnupiravir #COVID #twivtldr
Okay! One week since the dreaded pink line appeared on my rapid test, two days since finishing a course of Paxlovid antivirals, and today the pink line didn't appear. Here's how the last few days on an antiviral treatment went. Hopefully you'll never need to know but if you're unfortunate enough to need it, here's a bit of reassurance and a brief report.
https://www.ohaicorona.com/2023/5567/paxlovid-journal-days-345-and-7/
#paxlovid #antivirals #experience #covid
Current #outcomes of #SARS-CoV-2 #Omicron variant infection in high-risk #haematological patients treated early with #antivirals https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad105/7116669?rss=1
#outcomes #sars #omicron #haematological #antivirals
RT @MatToddChem
Protein science #postdoc available in my lab at @School_Pharmacy in central London working with READDI-AViDD team towards new #antivirals. https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?nPostingId=3304&nPostingTargetId=8387&id=Q1KFK026203F3VBQBLO8M8M07&LG=UK&mask=ext
2 yrs, with possibility of 2 more. Protein expression, assay development. Deadline Apr 16th
Scientists push to change COVID-19 antiviral guidelines to make medication more accessible in Australia.
#COVID19Aus #Antivirals
https://www.abc.net.au/news/2023-03-21/qld-covid-19-antiviral-medication-guidelines-access-australia/102120634
In New Zealand the Covid anti-viral Molnupiravir has proved only half as effective as Paxlovid, so it's off the menu.
#covid #antivirals #molnupiravir #Paxlovid #nz