CRISPR-activated Oct4 as #GeneTherapy for #Progeria (LmnaC698G) & natural aged🐭
#HutchinsonGilfordProgeriaSyndrome

Polyethylenimine-cationic gold nanoparticle iv.

Do we need an aortotropic vector for #AorticAneurysm?

Dr. Jongpil Kim lab @AgingCell 2023
https://onlinelibrary.wiley.com/doi/10.1111/acel.13825

Through Oct4 expression is only transiently activated for 2 weeks in 50% aortic SMCs (by day 5 delivery) in progeria mice, but with an amazing long-lasting benefits on SMC vitality, arterial stiffness, progerin, multi-organ ( kidney, spleen, muscle, lung, and skin) senescence transcriptional profile, lifespan w/o apparent dysplasia

#Cohesinopathy

BRD4 (acetyl lysine reader)-NIPBL (cohesin loading ) complex is critical to #NeuralCrest differentiation into #SmoothMuscleCell

BRD4 depletion->⏬#GenomeFolding+loop extrusion

BRD4 in #AorticAneurysm?

Dr. Rajan Jain lab Nature Genet 2021
https://www.nature.com/articles/s41588-021-00934-8

Thoracic #AorticDissection (type A+B) in Nova Scotia, Canada🇨🇦2005-2015

382 scheduled thoracic #AorticAneurysm repair
294♂️vs 88♀️

345 dissection events
212♂️vs 133♀️
4.4 vs 2.4 per 10,000 person-years🧐

Dr. Claudia Cote lab #CJCOpen 2022
https://www.cjcopen.ca/article/S2589-790X(22)00176-7/fulltext

Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve

How about TGFβ2/3?

As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels

Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w

Phospholipase Cε #Aortopathy

Plce1 KO🐭 are susceptible to ANGII-induced ascending #AorticAneurysm+Dissection

Role of adventitial myofibroblast cytokines?😎

Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00262.2022

Referenced link: https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1577675001960038400#m

RT by @physorg_com: Large study of thoracic #aorticaneurysm backs guidelines @JAMACardio https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html