#Astrocytic #APOE4 removal confers cerebrovascular protection despite increased cerebral #amyloid angiopathy - #APOE #cerebrovasculature #astrocyte - https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00610-x

What if you could remove #APOE4, the most important #genetic risk factor for #Alzheimers disease, from the brain? They did https://nature.com/articles/s43587-023-00368-3

Discoveries that the #APOE2 and #APOE4 genes may play a greater role not only as a predictor for #Alzheimers but also for more severe reactions to #Covid19, especially mortality.

https://www.rockefeller.edu/news/32732-common-gene-variant-linked-to-covid-mortality/

Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936

APOE4 status explains the majority of variance in cognitive aging when early-life and lifestyle factors are included in the same model.

(Open Access)
https://www.nature.com/articles/s41380-022-01900-4

#CognitiveAging #Apoe4 #earlylifefactors #lifestyle

Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936

APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.

(Open Access)
https://www.nature.com/articles/s41380-022-01900-4

#CognitiveAging #Apoe4 #earlylifefactors #lifestyle

@philshapiro NIH Study reveals how APOE4 gene may increase risk for dementia - women are at higher risk of inheriting this gene from each parent thus increasing the risk by 8 to 10 times. https://www.nih.gov/news-events/nih-research-matters/study-reveals-how-apoe4-gene-may-increase-risk-dementia #Dementia #APOE4 #gene Take #Cholinesupplements

RT @manoliskellis@twitter.com

This week in @Nature@twitter.com we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD

🐦🔗: https://twitter.com/manoliskellis/status/1594656572227084294

RT @manoliskellis@twitter.com

This week in @Nature@twitter.com we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD

🐦🔗: https://twitter.com/manoliskellis/status/1594656572227084294

RT @manoliskellis@twitter.com

This week in @Nature@twitter.com we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD

🐦🔗: https://twitter.com/manoliskellis/status/1594656572227084294

It’s well-known that carrying one copy of the #APOE4 gene variant increases one’s risk for #Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be done to help patients, remain largely unknown
#Neuroscience #sflorg
https://www.sflorg.com/2022/11/ns11222202.html

The #APOE4 gene variant is the strongest genetic risk factor for #Alzheimer disease. However, the effects of APOE4 on the human brain are not fully understood. A new study suggests that this risk gene may undermine insulation of the brain's wiring, opening opportunities to develop targeted therapies.

https://www.nature.com/articles/s41586-022-05439-w

News and views:
https://twitter.com/DrLiHueiTsai/status/1593082131449716736?s=20&t=Ec-nCdyjXknQ3WtWj24zYw

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins. PLoS One. 2016 Nov 8;11(11):e0166195.

https://www.ncbi.nlm.nih.gov/pubmed/27824936

Bleeding-edge research into how one might pharmacologically manage #Alzheimers pathology in #APoE4 brains yields striking positive results in mice. #ABCA1 #dementia #neuroscience #brainscience

#RandomJournalArticles