Laminar #ShearStress reduces plasma leakage and #atheroma formation in atheroprotected regions of the aorta through downstream polarization and endocytosis of VE-PTP and resultant activation of #Tie2. #Atherosclerosis can be suppressed by inhibition of VE-PTP in atheroprone regions that lack VE-PTP sequestration.

By D. McDonald, D. Vestweber & colleagues at MPI for molecular biomedicine & UCSFCancer

🗞️ https://doi.org/10.15252/emmm.202216128