https://m.youtube.com/watch?v=mJItu9LwJE0&pp=ygUhQXRoZXJvc2NsZXJvc2lzIGRyIG1pY2hhZWwga2xhcGVy
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#atherosclerosis

How Vitamin A and its derivatives contribute to #atherosclerosis. #ReviewedPreprint https://elifesciences.org/reviewed-preprints/87430?utm_source=mastodon&utm_medium=social&utm_campaign=organic

#pedscardio @Jhypertension In a population-based cohort followed for 20 years, higher BMI or waist-to-height ratio in childhood was significantly associated with greater cIMT and enhanced levels of proteins reflective of inflammation, supporting the importance of inflammation as progressive #atherosclerosis in childhood adiposity.
📌 https://journals.lww.com/jhypertension/Abstract/2023/03000/Associations_of_childhood_adiposity_with_adult.5.aspx?context=FeaturedArticles&collectionId=1

Is #atherosclerosis an #autoimmune disease? A team of researchers, led by Andreas J. R. Habenicht at LMU Munich & Changjun Yin at Sun-Yat Sen University, has shed light on this question and opened up potential avenues for new therapeutic interventions. Katrina Woolcock's thorough account of their publication in Nature Cardiovascular Research on https://new-ground.com/en/articles/single-cell-analysis-supports-a-role-for-t-cell-autoimmunity-in-atherosclerosis-and-helps-pave-the-way-for-new-immunotherapies/new-ground.2023.99892

Research in mice in @SciSignal reveals a role for the protein neuropilin-1 in supporting the barrier functions of #EndothelialCells in blood vessels and shows how a lack of the protein might exacerbate vascular diseases such as #atherosclerosis. https://scim.ag/2PH #press

Research in mice in @SciSignal reveals a role for the protein neuropilin-1 in supporting the barrier functions of #EndothelialCells in blood vessels and shows how a lack of the protein might exacerbate vascular diseases such as #atherosclerosis. https://scim.ag/2N1 #press

Lance Reddick died of ischemic heart disease and atherosclerotic coronary artery disease. It's a common misconception that only overweight or obese people develop plaque-clogged arteries. It can happen to anyone. 😧
#LanceReddick #HeartDisease #atherosclerosis
https://deadline.com/2023/04/lance-reddick-cause-of-death-the-wire-john-wick-1235319466/

Macrophage #DCLK1 promotes inflammatory #atherosclerosis by directly binding to IKKβ and activating IKKβ/NF-κB signal. #DCLK1 is a new regulator of IKKβ and a potential therapeutic target for #atherosclerosis.

By Z. Huang, G. Liang & colleagues at Wenzhou Medical University

🗞️ Read #openaccess: https://doi.org/10.15252/emmm.202217198

Scientists regard sorghum as a potential #therapeutic agent against #atherosclerosis

https://www.naturalnews.com/2020-04-08-sorghum-potential-therapeutic-agent-against-atherosclerosis.html

Mechano-vulnerability of #EndothelialCell in #Atherosclerosis 🤠

EVA1A, elevated by #DisturbedFlow-Twist1 axis, blocks EC #Autophagy & induces #Apoptosis

Dr. Paul Evans & Jovana Serbanovic-Canic lab ATVB 2023
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318110

Interesting to note that LC3B in EC +72 h #DisturbedFlow is mostly lipidated (Fig. 4A)

Does this suggest that endothelium under #DisturbedFlow enter an Autophagy-dependent state? For Survival, Shear-sensing & Secretion? 🧐

RT @LarsMaeg
We are hiring PhD students with interest in #noncodingRNAs #atherosclerosis #vascularbiology #bioinformatics to join us @TU_Muenchen! Projects utilize various #Omics tools & datasets (incl. single cell and spatial). @ERC_Research @dzhk_germany
https://www.mri.tum.de/offene-stellen/aerzte-und-wissenschaftler/phd-vascular-biology-disease

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atheroscleros:

https://www.frontiersin.org/articles/10.3389/fphar.2023.1083875/full

#atherosclerosis

#LaminarShear pushes VE-PTP (How?🤓) to downstream pole of #EndothelialCell, followed by endocytosis->⏫p-Tie2

Potentially explain how #DisturbedFlow⏫#VascularPermeability & #Atherosclerosis

Inhibition of VE-PTP by AKB-9785 fortifies #EndothelialBarrier & reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)🐭

Nice comparison of anti-leakage strategies
VE-PTP inhibition
Angpt1 activation of Tie2
Angpt2 inhibition

Dr. Donald McDonald & Dietmar Vestweber labs EMBO Mol Med 2023
https://www.embopress.org/doi/

Laminar #ShearStress reduces plasma leakage and #atheroma formation in atheroprotected regions of the aorta through downstream polarization and endocytosis of VE-PTP and resultant activation of #Tie2. #Atherosclerosis can be suppressed by inhibition of VE-PTP in atheroprone regions that lack VE-PTP sequestration.

By D. McDonald, D. Vestweber & colleagues at MPI for molecular biomedicine & UCSFCancer

🗞️ https://doi.org/10.15252/emmm.202216128

My Plant Power Programs are now available FREE of charge. Please share them with your friends, family, patients, clients, colleagues, trainees, students, employees etc.. To get your free program, please go to https://www.praxiom.org/shopping-cart.htm #plantbased #atherosclerosis #heart

I've decided to offer my Plant Power books and infographics FREE of charge. Please share them with friends family, patients, clients, students, employees etc.. To order your free copy, go to https://www.praxiom.org/shopping-cart.htm #atherosclerosis

Postdoctoral Fellow @AmitabhCPandey

Looking for a motivated postdoctoral fellow to join us in research related to #genomics and #molecular #mechanisms of #atherosclerosis. #NOLA

https://jobrxiv.org/job/tulane-university-health-sciences-center-school-of-medicine-27778-postdoctoral-fellow/?feed_id=34998

#ScienceJobs #job #Sciencejobs #cardiovascul...
https://jobrxiv.org/job/tulane-university-health-sciences-center-school-of-medicine-27778-postdoctoral-fellow/?feed_id=34998

RT @c_j_d@twitter.com

Hi all, I’m looking to speak to a cardiologist to help with understanding arterial hardening in endurance athletes. If anyone can connect me (complete layperson) with someone knowledgeable for a chat that would be great #heart #cardiology #arteries #atherosclerosis

🐦🔗: https://twitter.com/c_j_d/status/1614925566670512129

A remarkable mechanism for #DisturbedFlow disruption of #EndothelialCell Junction in #Atherosclerosis

Disturbed Flow-activated GRK2 phosphorylates #Vinculin Ser721-> a closed conformation of Vinculin
->⏬VE-cad junction

Dr. Jeng-Jiann Chiu lab Euro Heart J 2022
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac647/6830649

Just Published!

"The Renin Angiotensin System in Cardiovascular Disease".

Read here: https://link.springer.com/book/10.1007/978-3-031-14952-8

This book covers the role of the renin-angiotensin system (RAS) in cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, heart failure, and others.

Enjoy!

#HeartHealth #HeartDisease #CardiovascularDisease #Physiology #Atherosclerosis #Arrhythmia #Hypertension #Covid19 #Books #BiomedicalResearch