Global #COVID monitoring is crashing as BA.2.86 #COVIDvariant raises alarm
The number of mutations in #BA2.86's critical #spikeprotein is over 30, rivaling the number seen in the original omicron subvariant, #BA1, which went on to cause a tidal wave of cases and hospitalizations. The spike mutations appear geared toward evading neutralizing #antibody protections built up from past infections and #vaccinations.
"This is on the shoulders of governments right now." https://arstechnica.com/health/2023/08/global-covid-monitoring-is-crashing-as-ba-2-86-variant-raises-alarm/
#covid #covidvariant #ba2 #spikeprotein #ba1 #antibody #vaccinations
Associations of #COVID19 #symptoms with #omicron subvariants #BA2 and #BA5, host status, and #clinical outcomes in #Japan: a registry-based observational study - Lancet ID.: https://doi.org/10.1016/S1473-3099(23)00271-2 #epidemic #pandemic #epidemiology
#COVID19 #symptoms #omicron #ba2 #BA5 #clinical #japan #epidemic #pandemic #epidemiology
Intrinsic and effective #severity of #COVID19 cases infected with the ancestral strain and #Omicron #BA2 #variant in #HK https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad236/7208626?rss=1 #epidemiology #cfr #resources #hospital #wuhan #china
#Severity #COVID19 #omicron #ba2 #variant #hk #epidemiology #cfr #resources #hospital #Wuhan #china
Long term anti- #SARS-CoV-2 #antibody #kinetics and correlate of #protection against #Omicron BA.1/ #BA2 infection https://www.nature.com/articles/s41467-023-38744-7
#sars #antibody #kinetics #protection #omicron #ba2
Real-world #effectiveness of primary series and #booster doses of inactivated #COVID19 #vaccine against #Omicron #BA2 #variant infection in #China: a retrospective cohort study https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad090/7099684?rss=1
#effectiveness #booster #COVID19 #vaccine #omicron #ba2 #variant #china
#Immunity of heterologous and homologous boosted or #convalescent individuals against #Omicron #BA1, #BA2 and #BA4/5 variants https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad057/7069351?rss=1
#immunity #convalescent #omicron #ba1 #ba2 #BA4
{#SARS-CoV-2 #Omicron} #BA1, #BA2 and #BA275 variants show comparable #replication kinetics, reduced impact on #epithelial #barrier and elicit cross-neutralizing #antibodies https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011196
#sars #omicron #ba1 #ba2 #ba275 #replication #epithelial #barrier #antibodies
Associations of #COVID19 Symptoms with #Omicron #Subvariants #BA2 and #BA5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan
- BA.5 infection associated with higher symptom burden than BA.2
- Omicron breakthrough-infected individuals with ≥ 3 vaccinations or previous infection were less likely to exhibit systemic symptoms, but more likely to exhibit upper respiratory symptoms.
https://www.medrxiv.org/content/10.1101/2023.02.02.23285393v1
#covid19 #omicron #subvariants #ba2 #BA5 #sarscov2 #SARS2
Associations of #COVID19 Symptoms with #Omicron #Subvariants #BA2 and #BA5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan
- BA.5 infection associated with higher symptom burden than BA.2
- Omicron breakthrough-infected individuals with ≥ 3 vaccinations or previous infection were less likely to exhibit systemic symptoms, but more likely to exhibit upper respiratory symptoms.
https://www.medrxiv.org/content/10.1101/2023.02.02.23285393v1
#COVID19 #Omicron #subvariants #ba2 #BA5 #SarsCoV2 #SARS2
Comparative #Effectiveness of #COVID19 #Vaccines in Preventing #Infections and Disease #Progression from #SARS-CoV-2 #Omicron #BA5 and #BA2, #Portugal https://wwwnc.cdc.gov/eid/article/29/3/22-1367_article
#effectiveness #COVID19 #vaccines #infections #progression #sars #omicron #BA5 #ba2 #portugal
Die #Omikron Variante #BA2 feiert ein erstaunliches Comeback, während BA5 weiter zurückgeht. Ich frag mich ob das nur an dem angepassten #Impfstoff liegt.
#Protection conferred by #Delta and #BA1 / #BA2 #infection against #BA4 / #BA5 infection and #hospitalization: A Retrospective Cohort Study, The Journal of Infectious Diseases, jiad003, https://doi.org/10.1093/infdis/jiad003
#protection #delta #ba1 #ba2 #infection #BA4 #BA5 #Hospitalization
''It is worth noting that #XBB is not a virus mutation, but a #recombinant strain of two #BA2 lineages, #BA2101 and #BA275. In contrast, the previous major epidemic strains in the United States, BQ.1 and BQ.1.1, both evolved from BA.5.''
#xbb #recombinant #ba2 #ba2101 #ba275
Li, M., Ren, Y., Aw, Z.Q. et al. Broadly neutralizing and protective #nanobodies against #SARS-CoV-2 #Omicron subvariants #BA1, #BA2, and #BA4/5 and diverse #sarbecoviruses. Nat Commun 13, 7957 (2022). https://doi.org/10.1038/s41467-022-35642-2
#Nanobodies #sars #omicron #ba1 #ba2 #BA4 #sarbecoviruses
#Effectiveness of #BNT162b2 and #CoronaVac #COVID19 #vaccination against asymptomatic and symptomatic #infection of #SARS-CoV-2 #omicron #BA2 in #HK: a prospective cohort study, https://doi.org/10.1016/S1473-3099(22)00732-0
#effectiveness #BNT162b2 #coronavac #COVID19 #vaccination #infection #sars #omicron #ba2 #hk
#Protection against symptomatic #infection with #delta (#B16172) and #omicron (#B11529) #BA1 and #BA2 #SARS-CoV-2 #variants after previous #infection and #vaccination in #adolescents in #England, August, 2021–March, 2022: a national, observational, test-negative, case-control study, https://doi.org/10.1016/S1473-3099(22)00729-0
#protection #infection #delta #b16172 #omicron #b11529 #ba1 #ba2 #sars #variants #vaccination #adolescents #england
Study in Nature: Enhanced #replication of #sarscov2 #Omicron #ba2 in human #forebrain and #midbrain organoids: BA.2 replicated more efficiently & triggered substantially higher levels of #apoptosis (cell death) in the infected human forebrain and midbrain organoids. https://www.nature.com/articles/s41392-022-01241-2
#apoptosis #midbrain #forebrain #ba2 #Omicron #sarscov2 #replication