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A project that started as a fun little side-project (structure-function comparisons in the CARD-CC family: CARD9, CARD10, CARD11 and CARD14). Then #serendipity happened: identification of activated CARD9 and CARD10 natural variants and novel disease association in #Genebass.
Activated CARD11 (causing B cell #lymphomas or #BENTA) and CARD14 (causing #psoriasis or #PRP) already known. With activated CARD9 and CARD10, we have activated variants in all 4 CARD-CC family members.