jobRxiv · @jobRxiv
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Ondine Cleaver · @ondinecleaver2022
121 followers · 95 posts · Server mas.to

Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.

When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced

Cool work spearheaded by grad student Haley Barlow.

biorxiv.org/content/10.1101/20

#SendFeedback #lumen #betacell #pancreas #devbiol #devbio

Last updated 3 years ago

Jing Hughes · @JingHughes
2 followers · 1 posts · Server mstdn.social

to

I am a and endocrinologist at WashU in St Louis.
 because it is the center of the cell and my world.
Unafraid to challenge convention and do difficult experiments (because we don’t know better).
Also because seeing is believing. 



Image credit and Alex Polino

#wucci #diabetes #signaling #betacell #cytoskeleton #center #cell #microscopy #primarycilia #biologist #islet #cilia #sciencemastodon #Introduction

Last updated 3 years ago