Postdoctoral Fellow in the Lilly Diabetes Center of Excellence of IBRI @INBiosciences
#Type1diabetes #CRISPR #betacell #autoimmunity #JDRFfunded
#ScienceJobs #job #type1diabetes #CRISPR #findingcure
Indianapolis #UnitedSt...
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Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.
When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced
Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback
#SendFeedback #lumen #betacell #pancreas #devbiol #devbio
#Introduction to #ScienceMastodon
I am a #Cilia #Islet #Biologist and endocrinologist at WashU in St Louis.
#PrimaryCilia because it is the center of the cell and my world.
Unafraid to challenge convention and do difficult experiments (because we don’t know better).
Also #Microscopy because seeing is believing.
#Cilia #cell #center #cytoskeleton #betacell #signaling #diabetes
Image credit #WUCCI and Alex Polino
#wucci #diabetes #signaling #betacell #cytoskeleton #center #cell #microscopy #primarycilia #biologist #islet #cilia #sciencemastodon #Introduction