RT @biorxivpreprint: Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification https://www.biorxiv.org/cgi/content/short/2023.08.31.555796v1 #bioRxiv https://www.biorxiv.org/cgi/content/short/2023.08.31.555796v1

Clearly, there is still much to learn about this corner of the dark genome defined by HEATR5 proteins and their co-factors.

#Biorxiv #Preprint #MembraneTraffic #DarkGenome #DarkProteome #RareDisease #AlphaFold #AlphaFold2 #ProteinPrediction #Golgi #Clathrin #CellBiology #biochemistry #Bioscience

RT @ProteomicsNews: This is the toolkit for easily visualizing single proteins from single cell proteomics data - from any software - that I was dreaming of and @awarshanna @jhupharmacology wrote it for me! - test data on our github or load your data here https://orsburnlab.shinyapps.io/SCPViz/SCP Viz - A universal graphical user interface for single protein analysis in single cell proteomics datasets https://biorxiv.org/cgi/content/short/2023.08.29.555397v1… #bioRxiv

A new #preprint #OpenScience #PeerReview by @PCI_Ecology: Michael Raatz (2023) Provision of essential resources as a persistence strategy in #foodwebs. #bioRxiv https://doi.org/10.1101/2023.01.27.525839

You may have seen it on #Biorxiv but, after adding data on #Fibroblast-tracks in #3D environments (and after paying 4151 €), here is the story published in @ScienceAdvances 🎉:
Fibroblasts generate topographical cues that steer cancer cell migration

https://www.science.org/doi/10.1126/sciadv.ade2120

"Here, we show that both offspring born to dams fed a high fructose diet and neonates exposed to high fructose exhibit decreased microglial density, increased uncleared apoptotic cells, and decreased synaptic pruning [...] cognitive defects and developed anxiety-like behavior which were rescued in GLUT5-deficient animals."

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment

Wang et al., #bioRXiv preprint 2023

https://www.biorxiv.org/content/10.1101/2023.08.14.553242v2

#neuroscience

A new #preprint #OpenScience #PeerReview by @PCI_Ecology: Marcelo A. Aizen et al. Being a #treecrop increases the odds of experiencing yield declines irrespective of #pollinator dependence. #bioRxiv https://doi.org/10.1101/2023.04.27.538617 🔽

On #biorxiv, what are the conditions for submitting an updated version of your preprint? It tells me that I have no papers that can be updated, but I have one in my author history.

Interesting pre-print on the metabolic interactions between species that drive #microbiome structure and function. Emphasises the importance of considering community-wide interactions when microbiome #engineering, rather than focusing on individual bugs.

#biorxiv #metabolism

https://www.biorxiv.org/content/10.1101/2022.01.26.477953v2

New #ISEPpapers #preprint! Presence of #vitaminB12 metabolism in the last common ancestor of land plants https://www.biorxiv.org/content/10.1101/2023.06.07.544158v1 #protists #algae #plants #vitamins #evolution #multicellularity #biorxiv

📰 "Effect of a topically applied gel containing antibodies from bovine milk on the relative abundance of Staphylococci in the canine skin microbiome"
by 🔬 Klaassens, E. S., Auxilia, S., Baak, M. L., Bongoni, R., van Damme, C. M. M., Bijker, S., Dietz, N., Winter, E., Broere, F., Foerster, B.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.29.551104v1?rss=1

📰 "Centrosome amplification primes for apoptosis and favors the response to chemotherapy in ovarian cancer beyond multipolar divisions"
by 🔬 Edwards, F., Fantozzi, G., Simon, A. Y., Morretton, J.-P., Herbette, A., Tijhuis, A. E., Wardenaar, R., Foulane, S., Gemble, S., Spierings, D. C. J., Foijer, F., Mariani, O., Vincent-Salomon et al.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550973v1?rss=1

📰 "Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function"
by 🔬 Galan, L., Alvarez-Villanueva, D., Maqueda, M., Barrero, M., IGLESIAS, A., Bertran, j., ALVAREZ, D., GARCIA-PRIETO, C., BALLARE, C., RODRIGUEZ-CORTEZ, V., BUENO, C., VIDAL, A., Villanueva et al.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550934v1?rss=1

📰 "Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injury"
by 🔬 Garcia, S. M., Diaz, A., Lau, J., Chi, H. M., Lizarraga, M., Davies, M. R., Liu, X., Feeley, B. T.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.551038v1?rss=1

📰 "Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction"
by 🔬 Poudel, S., Hyun, J. C., Hefner, Y., Monk, J., Nizet, V., Palsson, B. O.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.26.550757v1?rss=1

📰 "Emergence and spread of the barley net blotch pathogen coincided with crop domestication and cultivation history"
by 🔬 Taliadoros, D., Feurtey, A., Wyatt, N., Gladieux, P., Friesen, T., Stukenbrock, E. H.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550921v1?rss=1

📰 "Conserved atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory sensory neurons"
by 🔬 Vien, K. M., Duan, Q., Yeung, C., Volkan, P. C.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550990v1?rss=1

📰 "Neuroprotective role of lactate in a human in vitro model of the ischemic penumbra"
by 🔬 Cerina, M., Levers, M., Keller, J. M., Frega, M.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550936v1?rss=1

📰 "Unbiased method for spectral analysis of cells with great diversity of autofluorescence spectra"
by 🔬 Roet, J. E. G., Mikula, A. M., de Kok, M., Chadick, C. H., Garcia Vallejo, J. J., Roest, H. P., van der Laan, L. J. W., de Winde, C. M., Mebius, R. E.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.28.550943v1?rss=1

📰 "Inhibition of YAP the MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers"
by 🔬 Jessen, M., Gertzmann, D., Liss, F., Zenk, F., Baehner, L., Schoeffler, V., Ade, C. P., von Eyss, B., Gaubatz, S.
#bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.07.27.550917v1?rss=1