FedSearch - Federated network search engine

RT @EnzymeChemistry
Directed #Biosynthesis of Mitragynine Stereoisomers by Carsten Schotte, @JiangYindi, @grzechnydag, Thu-Thuy Dang, Larissa Laforest, Francisco León, Marco Mottinelli, Satya Nadakuduti, Christopher McCurdy, Sarah O’Connor @OConnor_lab at @MPI_CE in @J_A_C_S https://pubs.acs.org/doi/10.1021/jacs.2c13644

#biosynthesis

Last updated 1 year ago

Original post

LorenAmelang · @LorenAmelang

2 followers · 11 posts · Server neuromatch.social

@nadel
"Perhaps now would be a reasonable time to raise questions brought up by the personal histories published so far."

I appreciate the invitation! I'm still thinking about this bit of the Gyuri Buzsaki episode:

"What make the hippocampus special is the granule cell. There is no such cell type in the neocortex. Granule cells keep dividing postnatally and the only cell type known whose life depends on circulating hormones (steroids)."

I've found a few interesting links, including:

Estrogen modulates place learning through estrogen receptors in the hippocampus - Lilia Zurkovsky 2006
(Where they implanted the hormones directly into the rat hippocampus...)

Estrogen Receptors, the Hippocampus, and Memory - Linda A. Bean 2014
(Where they used receptor knockout mice and viral vector delivery of different estrogen receptors to modify the sensitivity to estrogen.)

Do you know of anyone studying this in humans? I guess it would be difficult, since as I (barely and maybe wrongly) understand things, our estradiol level above the blood-brain barrier is higher and poorly correlated with the testable levels circulating below there. And hippocampal E2 is mostly created in the hippocampus itself...

Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids - Yasushi Hojo 2018
https://www.frontiersin.org/articles/10.3389/fendo.2018.00183/full

"Penetration of plasma E2 into the hippocampus, however, is not able to account for the level of hippocampal E2 because hippocampal E2 is much higher than that in plasma."

This graphic is fascinating:
https://www.frontiersin.org/files/Articles/357380/fendo-09-00183-HTML-r1/image_m/fendo-09-00183-g001.jpg

Would love to hear anyone's thoughts on the influence of estrogen on spatial awareness and memory!

#hippocampus #estrogen #estradiol #neurosteroids #biosynthesis #GranuleCell

#hippocampus #estrogen #estradiol #neurosteroids #biosynthesis #granulecell

Last updated 2 years ago

Original post

CellBioNews · @cellbionews

24 followers · 468 posts · Server scientificnetwork.de

Secret recipe for #limonoids opens door for #bee-friendly #crop protection.

#insecticides #genomics #chinaberry #Melia #biosynthesis #agriculture

https://phys.org/news/2023-01-secret-recipe-limonoids-door-bee-friendly.html

#limonoids #bee #crop #insecticides #genomics #chinaberry #melia #biosynthesis #agriculture

Last updated 2 years ago

Original post

CellBioNews · @cellbionews

20 followers · 299 posts · Server scientificnetwork.de

Engineered #poplar #lignin has more of a valuable 'clip-off' chemical

#biotechnology #biosynthesis #pHB

https://phys.org/news/2023-01-poplar-lignin-valuable-clip-off-chemical.html

#poplar #lignin #biotechnology #biosynthesis #phb

Last updated 2 years ago

Original post

JIPB · @JIPB

32 followers · 103 posts · Server mstdn.science

Open media

Enjoy #free access to today's #JIPB paper, where Wu et al. reveal new details of #SalicylicAcid #biosynthesis.
https://doi.org/10.1111/jipb.13410
@wileyplantsci
#phytohormones #Arabidopsis #PlantScience

#free #JIPB #salicylicacid #biosynthesis #phytohormones #arabidopsis #plantscience

Last updated 2 years ago

Original post

Joseph P. · @tonic

229 followers · 118 posts · Server mstdn.science

Open media

Adenosine, a #biochemical that is found in cells and is essential for many processes. Adenosine is made up of an adenine nitrogenous base linked to a #ribose sugar #molecule. It is involved in the #biosynthesis and #replication of #DNA and #RNA, and is also a component of an #enzyme called S-adenosyl-L-methionine (SAM) and cyano-cobalamin (vitamin B-12). #Adenosine was once thought to only modify #cardiovascular #physiology, but now it is known to have many other effects on physiology.

#biochemical #ribose #molecule #biosynthesis #replication #DNA #RNA #Enzyme #adenosine #cardiovascular #physiology

Last updated 2 years ago

Original post