And herein lies the dirty little secret… We all know that the #COVID19 #vaccines aren’t intended to protect vs infection. The rub: last year’s #bivalent vax provided addt’l protection vs hosp/critical illness for only ~2 mos, before effectiveness waned. Frustrating, to say the least.

However, recall that the vaccines have been shown to reduce the chances of developing #LongCovid (varies btwn 15-40%.) So, might want to factor this into your decision-mkg.

Good discussion 1/2

[Pre-print] Faraone et al, 2023: Serum from people who received BA.4/5 #bivalent vaccines, many of whom had recent #COVID19 infections, still showed a 10x drop in neutralization for EG.5.1 (vs. BA.4/5). EG.5.1 is antigenically distant from XBB.
https://www.reddit.com/r/COVIDZero/comments/16fb9rp/preprint_faraone_et_al_2023_serum_from/

the bizarrest thing just happened. NJ health dept called my spouse with advice on getting the #bivalent booster even tho they have him in record for getting 2 #Novavax
He’s such a goody-2-shoes he gave them his real☎️📞🤦🏻‍♀️

Firstly, new updated boosters are coming out in 2-3 weeks plus the bivalent is useless AND he clearly prefers Novavax

This is a #DIY pandemic which is tbh… f%£ing frightening

The stuff I’m reading in Covid Cautious NYC FB is often 🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️& i dare not say anything b/c #noGoodDeed

“There was a small but significant increase in peak neutralizing antibody responses against #Omicron #BA5 and #XBB15 following the first #bivalent #booster, but no significant increase in peak titers following the second bivalent booster. Omicron-specific #neutralizing titers remained low after both doses of the BA.5 bivalent booster.” https://mstdn.social/@erictopol/110894423101207690

Effectiveness of #bivalent #mRNA #vaccines against medically attended symptomatic #SARS-CoV-2 #infection and #COVID19-related #hospital admission among SARS-CoV-2-naive and previously infected individuals: a retrospective cohort study, Lancet Infect Dis.: https://doi.org/10.1016/S1473-3099(23)00373-0 #research #medicine #pandemic

@Njord
I’m so glad you made that decision💜💜💛Many people won’t do it & can understand their point of view as I had real angst about it last year, but it angered me PH held back #Novavax until everyone got #Moderna #Pfizer #bivalent #boosters

The calendar on approval doesn’t lie. Made me super mad, however worked out for me as decided then & there I needed primary doses++

wasn’t going to get #SARS2 for innocuously taking out trash & it has tbh, FAR exceeded my expectations

Can someone who knows about #covid and #vaccines tell me where I can find more info on how people should go between booster shots? (In the US). Also info about whether with current strains the #bivalent booster is still the best option or whether #novavax might make more sense? Thanks and sorry for all the annoying hashtags, not that many people follow me 🤷

[Correspondence] #Bivalent #COVID19 #mRNA #vaccine against #omicron #subvariants in immunocompromised patients https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00357-2/fulltext?rss=yes #immunology #publichealth #epidemiology

@RedFaster Very nice, Sergei, you must think that you have now adroitly managed to twist my twisting of your words, that tried to twist my original post, to suit your disinformation agenda. I do remember blocking you, Sergei, the first time round, but you've just jumped servers, to take another kick at the can, which I am now calling you out for, publicly. See how that works? Get your shingles shot(s) Sergei! Oh, and your #COVID #bivalent booster. #VaccinesWork #GetVaccinated

Our fall COVID boosters will likely be a monovalent XBB formula - Enlarge / Vials with COVID-19 vaccine labels showing logos of pharmaceu... - https://arstechnica.com/?p=1948365 #annualvaccine #fallvaccine #monovalent #sars-cov-2 #bivalent #covid-19 #seasonal #science #omicron #xbb.1.5 #health #cdc #fda #flu #xbb

Ars Technica: Our fall COVID boosters will likely be a monovalent XBB formula https://arstechnica.com/?p=1948365 #Tech #arstechnica #IT #Technology #annualvaccine #fallvaccine #monovalent #SARS-CoV-2 #bivalent #COVID-19 #seasonal #Science #omicron #XBB.1.5 #Health #CDC #fda #flu #XBB

#CDC desperately urging people to get injected with #bivalent #mRNA #booster doses

https://www.naturalnews.com/2023-06-09-cdc-boosters-little-remaining-protection-covid-hospitalization.html

“This fall, millions of Americans might be lining up for yet another kind of #COVID #vaccine: their first-ever dose that lacks the strain that ignited the pandemic more than three and a half years ago. Unlike the current, #bivalent vaccine, which guards against two #variants at once, the next one could, like the first version of the shot, have only one main ingredient—the spike protein of the #XBB.1 lineage of the #Omicron #variant, the globe’s current dominant clade.” https://mastodon.social/@grandmastershah/110469482645282873

"ATAGI has reviewed the available evidence and advises that for people aged 12 years or older, a bivalent COVID-19 vaccine is now preferred over original (ancestral) vaccines for primary vaccination"

#COVID19Aus #bivalent #COVIDvaccine
https://www.health.gov.au/news/atagi-advice-on-the-preferential-use-of-bivalent-covid-19-vaccines-for-primary-vaccination-of-people-aged-12-years-or-older

Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness Among Adults with and Without Immunocompromising Conditions — | MMWR https://www.cdc.gov/mmwr/volumes/72/wr/mm7221a3.htm “Among adults without immunocompromising conditions, #bivalent #booster #vaccine effectiveness (VE) against #COVID19–associated #hospitalization declined from 62% at 7–59 days #postvaccination to 24% at 120–179 days compared with VE among #unvaccinated adults.”

“The #bivalent #COVID19 #vaccine given to working-aged adults afforded modest protection overall against COVID-19 while the #BA.4/5 lineages were the dominant circulating strains, afforded less protection when the #BQ lineages were dominant, and effectiveness was not demonstrated when the #XBB lineages were dominant.” https://bird.makeup/users/tryangregory/statuses/1659649111119757312

Dr. Griffin went through the whole thought process of fully vaccinating 6mo-4yo for #COVID in this current #bivalent-only world. (Especially for #kids who are partially vaccinated with a monovalent.) If #Pfizer, at least 3 doses, making sure one of the doses is a bivalent. If #Moderna, at least 2 doses, making sure one of the doses is a bivalent. 5/

#TWiVTLDR

“The authors also compared the #VE of #bivalent #vaccines against monovalent vaccines administered 3 to 6 months prior. They found the VE of bivalent vaccine (regardless of subvariant targeted) versus monovalent vaccines post-3 to 6 months was 35% (95% CI, 15% to 51%), while VE comparing bivalent vaccine versus monovalent vaccines post-6 months was 46% (95% CI, 30% to 58%).”

https://www.cidrap.umn.edu/covid-19/bivalent-covid-vaccine-shows-good-omicron-protection-while-older-version-wanes “The VE of #bivalent #vaccine (regardless of which subvariant the vaccine targeted) was 72% (95% confidence interval [CI], 61% to 80%) against #Omicron infection. When broken down by subvariant targeted in the bivalent vaccine, the VE of BA.1-containing bivalent vaccine was 65% (95% CI, 47% to 77%) and the VE of BA.4/BA.5-containing bivalent vaccine was 76% (95% CI, 65% to 83%).”

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad240/7148518 “In this multi-center prospective test-negative case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing #bivalent COVID#19 #mRNA #vaccines against #symptomatic #infection during the BA.5-dominant period was high compared to no vaccination (65% and 76%) and moderate compared to #monovalent vaccines administered over half a year before (46% combined).”