The EMBO Journal · @embojournal
441 followers · 172 posts · Server sciencemastodon.com
What controls basal, #Parkin-independent #mitophagy?
E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively
#parkin #mitophagy #Ubiquitin #ligase #vhl #fbxl4 #nix #bnip3
The EMBO Journal · @embojournal
419 followers · 122 posts · Server sciencemastodon.com
How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?
Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase
#encephalomyopathic #mtdna #mitochondrial #mitophagy #bnip3 #fbxl4 #Ubiquitin