Brick · @old_angry_queer
52 followers · 783 posts · Server girlcock.club
The EMBO Journal · @embojournal
453 followers · 212 posts · Server sciencemastodon.com
A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle
#transcription #rbm10 #splicing #mrna #brca1 #cellcycle
The EMBO Journal · @embojournal
451 followers · 200 posts · Server sciencemastodon.com
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565
#brca1 #e3 #ligase #nucleosome #chromatin #ubiquitylation #DNARepair
Kenneth P Mitton · @kpmitton
122 followers · 1080 posts · Server techhub.socialThe BRCA1 gene variant, causing cancer (breast, ovarian), traced back to a Scottish island.
#brca1 #breastcancer #ovariancancer
Stripymoggie · @Stripymoggie
269 followers · 517 posts · Server mastodon.ieBBC News - Breast cancer gene linked to Orkney islands
#Genetics #BRCA1 #Orkney
https://www.bbc.co.uk/news/uk-scotland-highlands-islands-64951429
Scientific Frontline · @sflorg
669 followers · 1678 posts · Server mastodon.social
Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html
#brca1 #brca2 #genes #ovarian #breast #pancreatic #prostate #cancer #medical #biology #sflorg
Gopishankar Thirumoorthy · @gopishankar
8 followers · 9 posts · Server genomic.social
RT @CeMM_News@twitter.com
In their new @CellReports@twitter.com paper, researchers from former CeMM PI & @MedUni_Wien@twitter.com Assoc. Prof. Joanna Loizou (@LoizouJoanna@twitter.com) demonstrate how inhibiting the POLΘ enzyme can stop the growth of #cancer cells with mutations in #BRCA1 ✂️🧬 ➡️ https://bit.ly/3tBIc2l
🐦🔗: https://twitter.com/CeMM_News/status/1593312399695777793