RT @HartungIngo
The mystery why #BRD4 is so easily degradable by various #PROTACs seems to be solved: because it doesn’t need much to glue BRD4 to the E3 ligase #DCAF16. Stunning. I need to free up time today to read the 2 new papers @biorxivpreprint following the recent AbbVie paper @ACSBioMed!

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473