Agitation
Treat with brexpiprazole
A first antipsychotic
FDA fast-tracks the drug
Dementia response

#dementia #brexpiprazole #antipsychotic #fda #agitation #cinquain #poetry

http://www.medicalnewstoday.com/articles/fda-fast-tracks-brexpiprazole-for-dementia-what-you-need-to-know

Summary Trial 3 #brexpiprazole 2 or 3mg associated with statist. signif. greater improvement vs. placebo in primary and key secondary efficacy endpoints in #Alzheimers #CTAD22

#Agitation in Alzheimer’s Dementia: #Brexpiprazole phase III trial- George Grossberg #CTAD22
previous trials https://www.sciencedirect.com/science/article/pii/S1064748119305214
Trial 3: use of 2mg and 3mg
- Design: randomized 2:1 2mg oder 3mg vs. Placebo
- Results: 2 or 3mg significant improvement
- Safety: AE - similar rates than placebo, sedation, extrapyramidal disorders, falls - only few reported on that, 3mg higher rate on discontinuation - no consistant pattern pattern in this group