#medicalinnovation #innovationinhealthcare #mednewsweek #jeffkarp #harvardmedicalschool #harvardstemcellinstitute #broadinstitute #brighamandwomenshospital #healthcareinnovation #healthtech #biotech #stemcellresearch #painmedicine #perioperativecare #anesthesiology #tedmed

#PrimeEditing is a new #GenomeEditing technology that promises to fix #SickleCellDisease-causing mutations in a curative approach. Discover more about this technology, a collaboration of #StJude and the #BroadInstitute of MIT and #Harvard. https://bit.ly/3A5CbOP

#StJude & #BroadInstitute #scientists are undertaking the first global & comprehensive examination of the #genomic, #genetic & molecular basis of #antifungalresistance in the emerging multi-drug resistant fungal pathogen #CandidaAuris. Dr. David Rogers, St. Jude: “Understanding the basis of antifungal resistance is essential for developing tools to better redirect response to therapy, to aid rational drug design & development & to assist in epidemiologic tracking of the spread of resistance."

#EricLander returning to #BroadInstitute, prestigious #genome research center he helped launch and led for 16yrs, one year after #WhiteHouse exit over bullying allegations. Lander will resume tenured faculty positions he left behind at #MIT and #Harvard https://bit.ly/3JIdPAT

2/ This work started w a tweet that came from crunching Delta data for one of my many COVID updates at the #BroadInstitute Then, in a day Pierre probably came to rue, I sent him an email (subj: "Is this interesting?") to see if he wanted to add rigor.

Pierre has just the skillset to ask this rigorously: an ID doc w a PhD on mathematical modeling of microbial population dynamics.

https://www.broadinstitute.org/blog/whyiscience-qa-how-physician-scientist%E2%80%99s-clinical-experience-shapes-his-infectious-disease

Though his main project in my lab is on sepsis, he dug in "on the side".

Proud to see Pierre Ankomah's work out at Open Forum Infectious Diseases! #BroadInstitute @mgh_id

We found (to our surprise) neither Delta nor Omicron took over faster in more vaccinated US states – we’d thought vaccination might select for immune-evasive Omi.

https://academic.oup.com/ofid/article/9/12/ofac621/6916970

Brief thread on this paper & its origin story, which took over a year in the end to get right! (I'm new at Mastodon threads; will try making subsequent posts unlisted, as some suggested… 🤞)

#introduction I am a research scientist at the #BroadInstitute in #Cambridge with an interest in #Ubiquitin #ligase #structuralbiology and #mechanisms. Here for the #science toots about #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #CryoEM

Thankfully,
Fernanda Garcia Fossa (https://twitter.com/GarciaFossa) from Marcelo Bispo de Jesus's (https://twitter.com/bispolino) lab and Mario Cruz (https://twitter.com/mccruz07) have teamed up to show you just how to do it!
They've created two great workflows that help you draw interpretations from Cell Painting profiles - the first using Morpheus, an easy-to-use web tool from the
#broadinstitute
that we've demonstrated before (https://twitter.com/CiminiLab/status/1559656101523726345) makes analyzing profiling data much easier! 3/x

#Introduction Part 1:
Hi! I'm a mid-career scientist at the Broad Institute in Cambridge Massachusetts USA and I tend to follow conversations about the career side of science and how to make it a more humane and equitable path. I've been told I have an "overdeveloped" sense of justice/conscientiousness. I have 5 kids; between science and family I've no other hobbies :D
#BroadInstitute #CompBio #ComputationalBiology #STEM #DEI #academia

How does APOE4 affect #humanbrain in #Alzheimer’s disease?

The new paper on @Nature by our Jose Davila-Velderrain, Group Leader at the #Neurogenomics Research Centre, and colleagues at the Massachusetts Institute of Technology and the #BroadInstitute of #MIT and #Harvard, led by Li-Huei Tsai, paves the way for the development of novel therapeutic strategies for AD.

#science #sciencemastodon #lifesciences #lifescience #neuroscience

https://humantechnopole.it/en/news/how-apoe4-affects-human-brain-in-alzheimers-disease/