@jonaskunst

Re: #Temelimab (Anti HERV-env)

#PathogenicCoronaviruses are known for the severe amount of #Complement component activation provoked. In keeping with that, surface Complement Regulatory Protein #CD46 inducts HERV-Env via C3b attached to SCRs 2-4. Interestingly enough, the Split Complement products produced via CD46 mediated inactivation of #C3b and #C4b are #NRP1 ligands.

CD46 & HERV-Env: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291489/

NRP1: https://pubmed.ncbi.nlm.nih.gov/31572401/