Excellent editorial on the potential role of #magnesium in vascular #calcification in #CKD.

Nicely explains why measuring serum levels of magnesium is not sufficient and which hardships exist in estimating total magnesium levels.

#Nephrology

https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfad059/7091935

Here's a transmission electron microscopy (TEM) image of #bone showing mineralized #collagen and an #osteocyte lacuna containing microcalcifications of #apatite and #whitlockite.

Such #calcification or #mineral formation is part of normal physiological processes such as #apoptosis but can also indicate #pathology.

The specimen was prepared using focussed ion beam scanning electron microscopy (FIB-SEM).

Read more:
https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.7b02888

#ThinSectionThursday #Biomaterials #ElectronMicroscopy

RT @NatRevRheumatol@twitter.com

Read our #Review on the molecular processes involved in #cartilage #calcification in #osteoarthritis, including therapeutic pathways and new drugs to decrease joint calcification.

https://bit.ly/3WFlyCH

🐦🔗: https://twitter.com/NatRevRheumatol/status/1606618239513018369

#SmoothMuscleCell Piezo1 promotes high Phosphate-induced #Calcification & osteogenic differentiation of cultured👤aortic SMC (& culture🐭aorta)

How Piezo1-Ca2+ elevates expression of Runx2 & Transglutaminase 2?

Dr. Beatrix Dienes lab Front Physiol 2022
https://www.frontiersin.org/articles/10.3389/fphys.2022.1037230/full

"Importantly, our calculations also include the potential mitigation of mid-day pCO2 by an enriched macroalgal community, which is likely to dissipate with #ClimateChange, as the 3D structure of coral reefs and the retention of water it creates collapses."

#Ocean #warming and #acidification uncouple #calcification from calcifier biomass which accelerates #CoralReef decline
(Sophie Gwendoline Dove et al, 2020)
https://www.nature.com/articles/s43247-020-00054-x

#COP15

#Kerterre, une autre façon d'habiter et de vivre, plus en harmonie avec la #nature.

C'est très inspirant!

Le fait que le mélange utilisé devient dur comme la pierre ( #calcification ) rend l'ensemble durable et pérenne.

#habitat #autoconstruction #chanvre #chaux

https://www.youtube.com/watch?v=oMIuQpqlIs8

#Kerterre, une autre façon d'habiter et de vivre, plus en harmonie avec la #nature.

C'est très inspirant!

Le fait que le mélange utilisé devient dur comme la pierre ( #calcification ) rend l'ensemble durable et pérenne.

#habitat #autoconstruction #chanvre #chaux

https://www.youtube.com/watch?v=oMIuQpqlIs8