Strong #CD4 T-Cell Responses to Ancestral and #Variant Spike Proteins Are Established by NVX-CoV2373 SARS-CoV-2 Primary Vaccination https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad163/7175115?rss=1

https://www.cell.com/cell/fulltext/S0092-8674(23)00403-8 “#BNT162b4 encodes variant-conserved, immunogenic segments of the #SARSCoV2 #nucleocapsid, membrane, and ORF1ab proteins, targeting diverse #HLA alleles. BNT162b4 elicits polyfunctional #CD4+ and #CD8+ #Tcell responses from diverse #epitopes in animal models, alone or when co-administered with BNT162b2 while preserving spike-specific immunity. Importantly, we demonstrate that BNT162b4 protects hamsters from severe disease and reduces viral titers”

RT Paul Ogongo
Our latest work show #IL17 #CD4 #Tcells are preserved in HIV-ART. We identify two subsets of #Th17 cells; 1 specifically enriched for IL17 production to #Mtb but not CMV or SEB; and link between IDO-1 activity and circulating Th17 cells.@AnthonyVanTran @UCSF_EXPM @UCSF_GIVI_CFAR

M. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV biorxiv.org/cgi/content/sh… #biorxiv_immuno

tho always weird to give a seminar to myself, it's done! have a listen here if you like: https://youtu.be/i0GAhB3a2F8
the 2nd half is *unpublished* data on #tissue #CD4 #Tcells during #influenza and how they fit into a network of #CD8 #Bcells, #IgA & #NKcells.

I've received feedback from someone working on tumors that some of it brings new perspective on his data. In return I learned some new stuff about bladder cancer.

This open exchange of ideas is why I'm a scientist.