#Antiviral effect of #SARS-CoV-2 N-specific #CD8 T cells induced in #lungs by engineered extracellular vesicles https://www.nature.com/articles/s41541-023-00686-y

https://www.cell.com/cell/fulltext/S0092-8674(23)00403-8 “#BNT162b4 encodes variant-conserved, immunogenic segments of the #SARSCoV2 #nucleocapsid, membrane, and ORF1ab proteins, targeting diverse #HLA alleles. BNT162b4 elicits polyfunctional #CD4+ and #CD8+ #Tcell responses from diverse #epitopes in animal models, alone or when co-administered with BNT162b2 while preserving spike-specific immunity. Importantly, we demonstrate that BNT162b4 protects hamsters from severe disease and reduces viral titers”

#SARSCoV2 infection weakens immune-cell response to vaccination

NIH-funded study suggests need to boost #cd8+ T cell response after infection.

https://www.nih.gov/news-events/news-releases/sars-cov-2-infection-weakens-immune-cell-response-vaccination

Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post #SARSCoV2 infection

cell.com/immunity/fulltext/S1074-7613(23)00125-5

Antitumor T-cell function requires #CPEB4-mediated adaptation to chronic #endoplasmic #reticulum stress

Raúl Méndez and colleagues at IRB Barcelona show that RNA-binding protein CPEB4 mediates transient unfolded protein response #UPR for stress adaptation in #CD8 #Tcells

https://www.embopress.org/doi/10.15252/embj.2022111494

.@mhd Really Got To The Heart Of The City’s Role In The Conflict Between Tenants And Landlords When Speaking Yesterday About The Just Cause Eviction Amendment

#Marqueece
#MarqueeceHarrisDawson
#CD8
#LosAngeles
#LACityCouncil
#Eviction
#ShelleyVKraemer
#StateViolence

https://chez-risk.in/2023/01/21/marqueece-harris-dawson-really-got-to-the-heart-of-the-citys-role-in-the-conflict-between-tenants-and-landlords-when-speaking-yesterday-about-the-just-cause-eviction-ordinance/

RT @DrFAlzaid@twitter.com

New curated articles👇🏽
📰#Mitochondrial signal transduction(📷)
📰Clonal lineage tracing: mechanisms of #CD8 #Tcell fate decisions in chronic #infection
🩸#Glycomics array establishes anticarbohydrate antibody repertoire in #type1diabetes
🔗http://biomed.news/bims-nimamd/2022-11-06
🙏🏽@biomednews@twitter.com

🐦🔗: https://twitter.com/DrFAlzaid/status/1603362485704175617

tho always weird to give a seminar to myself, it's done! have a listen here if you like: https://youtu.be/i0GAhB3a2F8
the 2nd half is *unpublished* data on #tissue #CD4 #Tcells during #influenza and how they fit into a network of #CD8 #Bcells, #IgA & #NKcells.

I've received feedback from someone working on tumors that some of it brings new perspective on his data. In return I learned some new stuff about bladder cancer.

This open exchange of ideas is why I'm a scientist.