The EMBO Journal · @embojournal
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Keisuke Shigeta et al (Keio University School of Medicine) analyze #metabolic alterations leading to #chemoresistance in #urothelial cancer #bladdercancer: #IDH2 gain-of-function independent of #mutation is responsible for #HIF1α-dependent production of respective #gemcitabine and #CDDP competitors #dCTP and #NADPH
#metabolic #chemoresistance #urothelial #bladdercancer #idh2 #Mutation #hif1α #gemcitabine #cddp #dctp #nadph