:blobcatdance: Preprint drop: :blobcatdance:

"Optimized dimerization of the PAR-2 RING domain drives cooperative and selective membrane recruitment for robust feedback-driven cell polarization"

https://www.biorxiv.org/content/10.1101/2023.08.10.552581v1

#Polarity #CElegans #Science #research #Biochemistry

Fans of #Celegans will appreciate today's Research Highlight from Journal of Cell Science: Asako Sugimoto and colleagues identify unconventional subunits of the C. elegans γTuC microtubule nucleating complex acquired during its evolution, with important roles in embryonic development and germline maintenance. #microtubules #evolutionarybiology

Discovering divergent γTuC subunits in C. elegans
https://journals.biologists.com/jcs/article/136/13/e136_e1303/323431/Discovering-divergent-gTuC-subunits-in-C-elegans

It can be a bit disappointing when the mutant is just like the wild-type, but one can look at the bright side, it's just as beautiful as the wild-type. #DevBio #DevelopmentalBiology #CellBiology #CellBio #AsymmetricCellDivision #Celegans #Embryo

We had great time at #worm23 in Glasgow! For your trip home check out this fascinating interview with Piali Sengupta
@SenguptaLab
about the power of the #worm in studying #sensory mechanisms & her overall appreciation for the #wormcommunity!

👩🏽‍🔬https://journals.biologists.com/dmm/article/16/6/dmm050321/316657/ #Celegans

We're excited for #Worm23 @GeneticsGSA starting this weekend in Glasgow! To get you prepped, check out this fantastic Editorial from Guy Caldwell @Wormshack_UA @UofAlabama on how the humble #worm is now a robust #PreclinicalModel

🎇https://journals.biologists.com/dmm/article/16/6/dmm050333/316701/ @uab_neurology #Celegans #StarTrek

I teach a lab course on #Celegans looking at asymmetric cell division and embryo development in the par mutants. It's pretty low tech, with cheap dissecting scopes and microscopes, and it works pretty well. Anyway students realized years ago that one can take pictures with a smartphone directly on the eyepiece. Now one student even made a time lapse movie of the first division and put it on youtube. Made my day. #teaching #genetics
https://youtu.be/Q44twa9rrsU

Another neat worskhop @DGZ_info, talks by @IgnatovaLab @FranziskaOttens @_ilgink @TheVilchezLab.

I loved the story ER associated degradation & the "smurf assay" in #celegans by @Soto_Ef @FranziskaOttens, Shutter, et al.

Full: https://www.nature.com/articles/s41556-022-01025-4 #ER_literature #scicomm
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RT @DGZ_info
Join us for the next #DGZ Focus Workshop on Cellular and Organismal #Proteostasis on March 28, featuring @_ilgink, @TheVil…
https://twitter.com/DGZ_info/status/1633025784968359943

Word 👇🏻
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RT @GalHaspel
@Metabo_Dave @drugmonkeyblog Or switch to working on #celegans
The best scientific community
https://twitter.com/GalHaspel/status/1638658579887722497

You've heard of a lab-on-a-chip, now we've got a gym-on-a-chip or an "Acoustic Gym", as the University of Colorado researchers named it.

Understanding how exercise improves the neurogenic condition of Parkinson’s sufferers is complicated. So these scientists used some engineering to make it simpler, with genetically modified C. elegans and an incredibly tiny wave pool for swimming.

#Biology #Genetics #Medicine #Disease #Biotech #Parkinson's #Celegans

https://www.science.org/doi/10.1126/sciadv.adf5056

Flavin-containing monooxygenases rewire #metabolism to promote #longevity through #tryptophan and one carbon metabolism in #Celegans. https://www.nature.com/articles/s41467-023-36181-0

#https://doi.org/10.1101/2023.02.17.528811
Nice collaboration of @kaletalab and @EvoEcoGen_ (Schulenburg lab) in Kiel on dietary interventions in the #hostmicrobeinteractions - Marinos and Hamerich et al. using #metabolicmodelling predict supplementation of the #diet of #celegans to boost the abundance of the beneficial #Pseudomonas lurida MYb11 while decrasing #Ochrobactrum vermis MYb71 in the host. Serine, Threonine, Mannitol and GABA were confirmed in in-vivo/in-vitro experiments.

Indoor air quality (IAQ) has long been a concern for the health and wellbeing of anyone who is indoors (which is many of us a lot of the time).

But there are ongoing efforts to detect pollutants indoors and many methods have been developed.

Now, Finnish researchers have used a transgenic GFP producing C. elegans to use their own chemical senses to detect harmful compounds.

#Science #Genetics #Biology #Celegans #IAQ #Biotech #Biotechnology #sciencemastodon #scicomm

https://www.mdpi.com/2076-0817/12/2/161

Two new posts on preLights today! 👀

The other one has been written by Chee Kiang (Ethan) Ewe - postdoc in the #RechaviLab – who highlights work from the #BuelowLab.

This #preprint shows that the only constant is change – even in “hard-wired” C. elegans. The authors demonstrate the rewiring of an asymmetric neural circuit during associative learning.

📜 https://prelights.biologists.com/highlights/restructuring-of-an-asymmetric-neural-circuit-during-associative-learning/

#learning, #Celegans #insulin #signaling #neurogenetics

RT @utfriglowworms
We want to add some rab proteins and kinases to our target list for this year. If we can get some consensus targets (on wantlist of maybe 5+ research groups) that would be great. Feel free to post them here. #crispr #celegans

I've been #teaching an undergraduate lab course using #Celegans' early #embryos. It works pretty well, even a messy teacher like me can pull it off. It allows for students to experiment with both #DevelopmentalBiology #DevBio, #CellBiology #CellBio and #Genetics. For anyone interested on setting up a similar course here goes a short thread. The course is three 4h sessions in the span of a week. As material goes it requires dissecting scopes and basic light microscopes for all students 1/n

Today I'm teaching about #Celegans as model organism for #genetics. It's one of my favorite courses to teach every year. It's such a convenient model. Even if students will never use it in their research, it great to illustrate a lot of #genetic approaches and tools.
... and next week is the lab course. @worms

THREAD: Falls are a major public health problem — a top-20 cause of death in the US. Wonder what scientists are doing about that? @yunluzhu & colleagues in my lab developed powerful new tech to understand balance & evaluate therapeutics.
https://www.biorxiv.org/content/10.1101/2023.01.07.523102v1
Want to know more / watch neat movies? 1/9

#mastopiece #neuroscience #balance #drosophila #celegans #zebrafish

Thx for boosting (we’re trying to outdo that other place)!

Happy to share that the first article for 2023 is now online: #celegans #metabolomics #lipidomics #metallomics
https://pubs.acs.org/doi/10.1021/acs.jproteome.2c00578

...once one ruled that out one can go for the "what do they do". But no, when you read reviews or you listen to keynote talks on the subject we'll find somewhere 'oh, btw, it would be nice to know the function of these thingies'. Guess what? There's evidence that if they have a function is not essential, e.g. #Celegans embryos without #Pgranules - classic condensate! - are viable (see linked article from >10y ago). And that's not the only exemple, actually what is... 2/n

https://www.science.org/doi/10.1126/science.1193697

#introduction I work on (and am fascinated by) asymmetric #cell division, using the #Celegans embryo as model system. I use mostly #Genetics and #CellBiology, but I'll go with whatever approach allows me to answer a question.
Other than working with worms I'm interested in #Reproducibility and #OpenScience.
And, of course, #teaching, I really enjoy teaching.