#FGF modulates cell adhesion to help salivary glands branch out

A Research Highlight showcasing new work from Ayan Ray & Philippe Soriano

https://journals.biologists.com/dev/article/150/6/e150_e0601/297284/FGF-modulates-cell-adhesion-to-help-salivary

Read the full Research Article, 'FGF signaling regulates #SalivaryGland branching morphogenesis by modulating cell adhesion' here:

https://journals.biologists.com/dev/article/150/6/dev201293/297264/FGF-signaling-regulates-salivary-gland-branching

A reviewer said, "This linkage between FGF signalling and #CellAdhesion provides a useful new dimension to understanding the mechanisms of #FGFsignalling".

#devbio

Tong et al explore the conformational landscape of integrin αIIbβ3 from bent to extended states and the implication for adhesion stability.
"Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly"
https://doi.org/10.1016/j.bpj.2022.12.032
#Integrins #CellAdhesion

RT @stemcellpodcast
Dr. Adam Stevens (@stevenschem) and a group in Dr. Wendell Lim's lab at @CDI_UCSF engineered synthetic #CellAdhesion molecules that specify new and orthogonal connectivities between cells.

@Nature paper: https://go.nature.com/3kMhF1l

Discussion: https://bit.ly/3XUJUJr

Getting more comfortable here and so it’s time for an #introduction ?
I never planned on doing a PhD and certainly not on staying afterwards. But somehow I got hooked on #microscopy and #celladhesion and especially #integrins , more recently also #TGF s. So I stopped my high school teacher career and here I am… And if research also doesn’t work out I might pursue a career in integrin-themed cakes

Synthetic cell adhesion molecules (synCAMs) were generated by combining extracellular and intracellular adhesion domains from native molecules such as cadherins and integrins.

🔒 https://www.nature.com/articles/s41586-022-05622-z

#CellAdhesion #CellAggregate #TissuePatterning #MulticellularEvolution #SyntheticBiology #MolecularPharmacology #BioEngineering

Synthetic cell adhesion molecules (synCAMs) were generated by combining extracellular and intracellular adhesion domains from native molecules such as cadherins and integrins.

https://www.nature.com/articles/s41586-022-05622-z

#CellAdhesion #CellAggregate #TissuePatterning #MulticellularEvolution #SyntheticBiology #MolecularPharmacology #BioEngineering

https://www.nature.com/articles/s41586-022-05622-z

#CellAdhesion #CellAggregate #TissuePatterning #MulticellularEvolution #SyntheticBiology #MolecularPharmacology #BioEngineering

RT @RekadZeinab@twitter.com

Question to #celladhesion and #integrin fans, I'm writing my dissertation and I love adding some historical sparks. Shame on me, but I can't seems to find which group did the first ever biochemical characterization of integrin adhesions. (I mean, purification of the complexes)

🐦🔗: https://twitter.com/RekadZeinab/status/1596915315052793856

Question to #celladhesion and #integrin fans, I'm writing my dissertation and I love adding some historical sparks. Shame on me, but I can't seems to find which group did the first ever biochemical characterization of integrin adhesions. (I mean, purification of the complexes)

RT @JamesAGlazier1
Sequential changes in cellular properties accompanying amniote somite formation https://onlinelibrary.wiley.com/doi/10.1111/joa.13791#.Y4DvXFXKUfA.twitter

#development, #embryology, #quantiativebiology, #biology, #chick, #somites, #segmentation, #SEM, #celladhesion, #Cadherins

@soragnilab @MingqingCai @biorxivpreprint the problem with author-selected keywords is they are not helpful unless selected from a controlled vocabulary (e.g. #integrin will not show up in a search for #celladhesion) and then you have to decide/agree on and maintain the taxonomy (which is a nightmare). it's feasible for things like Human Phenotype Ontology, but that's the exception rather than the rule. search normally solves things but here that just means we're back to the original issue

#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!

#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz

#introduction:
I am a Lecturer and #NewPI at the #UniversityOfManchester #UoM
I am interested in how cellular interactions with the tumour microenvironment control fundamental aspects of cancer cell behaviour, including regulation of gene expression.
In @thebyronlab, we combine #proteomics, #sequencing, #bioinformatics, functional #CellBiology, super-resolution #imaging and #cancer models, to discover new properties of cancer #CellAdhesion #networks.

#introduction
Hello, this is Jose M de Pereda and I run a research group at the Center for Cancer Research in #Salamanca (Spain) (#CSIC #USAL).
We study the structural and mechanistic basis of #integrin based #CellAdhesion complexes (mostly #Hemidesmosomes) and of #Rap1 signaling. Knowing in detail how these molecular systems work is essential to understand how they are altered in diseases.
We do multidisciplinary research: #StructuralBiology #Biochemistry, #Biophysics and a bit of #CellBiology

Added @mechanobio to this bot series. This one was more tricky, as it selects abstracts mentioning molecules/structures (#cytoskeleton, #celladhesion) and some mechanics/morphogenesis. There's still room for improvement, don't hesitate to comment! @bortzmeyer @DavidBrueckner