Second half of the "variation and information" session #CSSingleCells23
led off by Sam Morris of WashU
http://morrislab.wustl.edu/

Multi-omic lineage tracing: insights into reprogramming cell identity

her piece in *Development*, "The evolving concept of cell identity in the single cell era"

working on "induced hepatocytes", start with fibroblasts, via "induced endoderm progenitors"

new work on #adipocytes
https://www.biorxiv.org/content/10.1101/2023.06.01.543318v1

#reprogramming
#StemCells
#CellIdentity
#CellFate

1/2

Yogesh Goyal at Northwestern Feinberg
https://www.goyallab.org/

Topic:
Tracing rare cell plasticity and diverse fate decisions in single cancer cells

Begins with reference to (and pic of) Monod's *Chance and Necessity*
#CellFate
#SingleCell
#CSSingleCells23

Emphasizing non-genetic differences between cells, something we can only see at single-cell resolution

Refers to Luria & Delbruck 1943 about bacterial resistance (to phage), relevant to cancer resistance to therapy (selected)

1/2

A healing #wound is a microcosm of many cell states found during #organogenesis. In addition to dead and dying cells, one may find proliferating cells, migrating cells, and cells that are differentiating or switching fate. How is this multitude of cell states, often mutually exclusive, established and maintained for successful repair and #regeneration?

--from Primer by Tin Tin Su in @PLOSBiology

#developmentalbiology
#differentiation
#cellfate

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002155

Referenced link: https://phys.org/news/2023-05-unveiling-rna-guided-mechanisms-cell-fate.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-05-unveiling-rna-guided-mechanisms-cell-fate.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1663541862743912448#m

Unveiling the RNA-guided mechanisms driving #cellfate @NatureComms https://www.nature.com/articles/s41467-023-38436-2 https://phys.org/news/2023-05-unveiling-rna-guided-mechanisms-cell-fate.html

This study from Eric Lee et al. suggests that sequential events during the #quiescence to #proliferation transition establish patterns of follicle cell #differentiation in the #Drosophila #ovary:

https://journals.biologists.com/bio/article/12/1/bio059625/286422/Sequential-events-during-the-quiescence-to

#StemCells #Oogenesis #CellFate #Science #BiologyOpen #Biology #Development #DevBio #AcademicMastodon

Excited to share our latest paper on "Interface Surveillance", a tissue intrinsic defense system against aberrant cells.

elifesciences.org/articles/80809

#drosophila #epithelia #tumor #mutations #cellfate #cellcompetition #SFB850

@unifreiburg

In EMBO Journal issue 3:

Host #mucins negotiate peace with #toxigenic #Vibrio
Cytosolic #stressgranules relieve nuclear #ubiquitin-#proteasome system
#Smoothened #cholesterylation and ER exit links in #Hedgehog signaling
Developmental #cellfate decision control by #chromatin reader #TRIM33
Cover by Kimon Lemonides, Helen Walden et al

https://www.embopress.org/toc/14602075/2023/42/3

How does #chromatin reader #TRIM33 control #developmental #cellfate decisions?

Qiaoran Xi Lab at Tsinghua University finds that its embryonic #stemcell-specific recruitment into #PML #nuclearbodies regulates #Lefty1/2 expression upon #Nodal signaling

https://www.embopress.org/doi/10.15252/embj.2022112058

In single pancreatic cells responding to oxidative stress, JNK dynamics regulate an early trigger of cell death, #p53 controls late maintenance of cell cycle arrest &p38 controls a switch between JNK- and p53-dependent cell fate➡️ http://bit.ly/3UPf6YM E Batchelor (UMN Medical School) #QBio #cellfate #SystemsBiology

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu

RT @kalhorlab
Our prescriptive prospective study of retrospective #cellfate barcoding is published in @cellcellpress, showing how a cross-sectional measurement of lineage barcodes can be used to reconstruct longitudinal cell fate dynamics (1/3) #devbio #compbio #synbio https://www.cell.com/cell/fulltext/S0092-8674(22)01374-5#.Y35JIl8Ud-U.twitter

RT @kalhorlab@twitter.com

Our prescriptive prospective study of retrospective #cellfate barcoding is published in @CellCellPress@twitter.com, showing how a cross-sectional measurement of lineage barcodes can be used to reconstruct longitudinal cell fate dynamics (1/3) #devbio #compbio #synbio https://www.cell.com/cell/fulltext/S0092-8674(22)01374-5#.Y35JIl8Ud-U.twitter

🐦🔗: https://twitter.com/kalhorlab/status/1595455266182803457

With #TwitterMeltdown continues, our lab is looking for a RA. Please DM or rios@hku.hk
We have one project with exciting data open for you
#HKU #CellFate #Epigenome #Myeloid #Development

"[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
https://www.biorxiv.org/content/10.1101/2022.11.11.516212v1?rss=1
#DevBio #CellFate #GermLayers #morphogens #Differentiation