#IDMastodon #CellImmunity #Viralimmunology #CovidIsNotOver #MaskUp 😷 Host #mitochondria more than an organelle in #SARSCoV2 infection . when 🦠 hijacks mitochondrial function, this allows it to control the entire cell.Emerging evidence suggested that #SARSCoV2 hijacks the mitochondria of immune cells, proliferate in mitochondrial structures & impairs mitochondrial functions . The interaction of several #SARSCoV2 proteins with mitochondrial components components may occur.

#IDMastodon @cellreports #Cellimmunity #Tcellimmunity of vaccinated individuals against #omicron sub~variants remains largely intact due to the nature of polymorphic cell-mediated immune responses, may continue to contribute to prevention/limitation of severe #COVID19 manifestation. The findings are supportive for the suitability of Omicron BA.4/BA.5-adapted #CovidVaccines to boost neutralizing activity against some BA.4/BA.5-descendant variants.

#IDMastodon #Cellimmunity #Immunology @cellpress
Overview #Innateimmunity & #Interferon in #SarsCoV2 infection outcome
Nearly 700 Mil people worldwide have been infected with 🦠 the cause of #COVID19 @WHO 6.8 million people are known to have died from infection. Vaccination clearly protects against #COVID19 severity, wherein humoral immunity is the major biomarker & mediator of disease protection.1 Importantly, prior to vaccination and in nonvaccinated persons today

#IDMastodon #Cellimmunity @cellpress
understanding the #Innateimmunity Roles & the actions of type I & III interferons & they are essential for protection from #SARSCoV2 infection & #COVID19. Each is induced in response to infection & serves to restrict viral replication & spread while directing the polarization & modulation of the adaptive immune response .Contrasting roles of types I & III IFNs in #ViralClearance
https://www.cell.com/immunity/fulltext/S1074-7613(23)00275-3

#IDMastodon #viralimmunology #CellImmunity Understanding protective immunity to #COVID19 facilitates preparedness for future pandemics & combats new #SARSCoV2 variants emerging in the human population & phospholipid scramblase 1 (PLSCR1) as a potent cell-autonomous restriction factor against live #SARSCoV2 infection in parallel #genome-wide #CRISPR–#Cas9 screens of human lung epithelia & hepatocytes . before and after stimulation with IFNγ.

#IDMastodon #Viralimmunology #Cellimmunity #Immunology @nature I’m still 😷 & It’s another friday who are till 😷 out there beside me ? A high infection rate or high #viralload by #SARSCoV2 may lead to exaggerated #cytokine responses, which may contribute to tissue damage in #LongCOVID & severe #COVID19 .
📌https://www.nature.com/articles/s41423-023-01039-4
📌 https://www.nature.com/cmi/

#IDmastodon #neurocovid #viralimmunology #Cellimmunity @frontimmunol new insight into the impact of virus-specific cellular immunity on the pathogenesis of #longCOVID and pave the way for the rational design of predictive biomarkers and therapeutic interventions. #neurocovid is characterized by enhanced CD4+ & diminished CD8+ T cell responses to #SarsCoV2 Nucleocapsid protein @gemale10 et al
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155770/full

#IDMastodon @eLife #clinicalreview #Viralimmunology #Cellimmunity In this #ClinicalReview , multiple researchers with wide-ranging expertise in adult and #pediatricmedicine came together to review the role of the innate and adaptive immune systems in the pathogenesis of acute #SARSCoV2 infection and PASC / #LongCovid .The focus on immune mechanisms here emphasizes the dysregulation of immune processes that are intertwined with the #viralpersistence and tissue-specific pathologies

#IDMastodon #viralimmunology #Immunology #Cellimmunity @Nature Immune genes could play a part in the risk of needing #ICU when infected with #SARSCoV2. Genetic links to inflammatory responses & the activation of immune cells — identifies 49 genetic variants underlying critical #COVID19
📌https://www.nature.com/articles/d41586-023-01655-0?utm_medium=Social&utm_campaign=nature&utm_source=Twitter#ref-CR1
📌https://www.nature.com/articles/s41586-023-06034-3

#Immunology #idmastodon #Cellimmunity @Nature #SARSCoV2 #booster #immunizations in humans induce robust GC B cell responses & can generate de novo #Bcell responses targeting #Omicron sub-variant-specific epitopes.
📌 https://www.nature.com/articles/s41586-023-06025-4_reference.pdf
📌 https://www.nature.com/articles/s41467-023-37432-w
📌 https://www.nature.com/search?q=Covid19&order=relevance&date_range=2022-2023

@Nature #cellimmunity #Immunology #CellBiology #SARSCoV2 both induces #DNA damage and impairs its repair, ultimately causing cells to age and spread inflammation.
📌 https://www.nature.com/articles/s41556-023-01097-w
📌 https://www.nature.com/articles/s41556-023-01096-x
📌 https://www.nature.com/search?q=Covid19&journal=

#IDMastodon #Immmunology #CellImmunity #InnateImmunity @JEM Inherited MyD88 & IRAK-4 deficiencies are predisposed to #hypoxemic #COVID19 . The patients’ susceptibility to #SarsCoV2 can be attributed to impaired TLR7-dependent type I IFN production by pDCs, which do not sense #SARSCoV2 correctly
📌 https://rupress.org/jem/article/220/5/e20220170/213920/Humans-with-inherited-MyD88-and-IRAK-4
📌 https://rupress.org/jem/issue

#IDMastodon #Immunology #Cellimmunity @cellcellpress
TCell exhaustion & Chronic Viral infection . All little bit alarm(in) is not always too bad! Great story about how IL-33 shapes T cell populations during chronic viral infections
https://www.cell.com/immunity/fulltext/S1074-7613(23)00041-9?rss=yes&utm_source=dlvr.it&utm_medium=twitter

#IDMastodon #IDtwitter #Cellimmunity #Immunology #Clinicalreview #Biomarkers related to biological functions in #LongCovid .There are 113 biomarkers Cytokine/Chemokine ,Biochemical markers ,Vascular markers , Neurological markers ,Acute phase protein & Others @FrontMedicine
https://www.frontiersin.org/articles/10.3389/fmed.2023.1085988/full#.Y-EUQ5H5bZg.twitter

#Immunology #cellimmunity @PLOSBiology LRRC15 is not a #SarsCoV2 entry receptor but can suppress spike-mediated entry . LRRC15 is also expressed in fibroblast cells, the cells that control lung fibrosis, a disease which causes damaged and scarred lung tissue. #COVID19 can lead to lung fibrosis, and the finding may have implications for #LongCovid.
📌https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001967
📌 https://journals.plos.org/plosbiology/issue

#IDMastodon #CellImmunity #Immunology Evidence suggests that adipocytes in obesity might facilitate #SARSCoV2 replication, for it was only found in adipose tissue of individuals with overweight or obesity but not lean individuals who died from #COVID19. #adipocytes in #obesity: A perfect reservoir for #SARSCoV2 ?
📌 https://www.sciencedirect.com/science/article/pii/S0306987723000166
📌 https://www.sciencedirect.com/journal/medical-hypotheses/vol/171/suppl/C