TrangAston :verified: · @CastlTrAstonDrs
1414 followers · 3016 posts · Server med-mastodon.com

😷 Host more than an organelle in infection . when 🦠 hijacks mitochondrial function, this allows it to control the entire cell.Emerging evidence suggested that hijacks the mitochondria of immune cells, proliferate in mitochondrial structures & impairs mitochondrial functions . The interaction of several proteins with mitochondrial components components may occur.

#IDMastodon #cellimmunity #viralimmunology #CovidIsNotOver #MaskUp #mitochondria #SarsCoV2

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1361 followers · 2835 posts · Server med-mastodon.com

@cellreports of vaccinated individuals against sub~variants remains largely intact due to the nature of polymorphic cell-mediated immune responses, may continue to contribute to prevention/limitation of severe manifestation. The findings are supportive for the suitability of Omicron BA.4/BA.5-adapted to boost neutralizing activity against some BA.4/BA.5-descendant variants.

#IDMastodon #cellimmunity #tcellimmunity #omicron #COVID19 #CovidVaccines

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1361 followers · 2822 posts · Server med-mastodon.com

@cellpress
Overview & in infection outcome
Nearly 700 Mil people worldwide have been infected with 🦠 the cause of @WHO 6.8 million people are known to have died from infection. Vaccination clearly protects against severity, wherein humoral immunity is the major biomarker & mediator of disease protection.1 Importantly, prior to vaccination and in nonvaccinated persons today

#IDMastodon #cellimmunity #immunology #innateimmunity #interferon #SarsCoV2 #COVID19

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1337 followers · 2702 posts · Server med-mastodon.com

@cellpress
understanding the Roles & the actions of type I & III interferons & they are essential for protection from infection & . Each is induced in response to infection & serves to restrict viral replication & spread while directing the polarization & modulation of the adaptive immune response .Contrasting roles of types I & III IFNs in
cell.com/immunity/fulltext/S10

#IDMastodon #cellimmunity #innateimmunity #SarsCoV2 #COVID19 #viralclearance

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1337 followers · 2688 posts · Server med-mastodon.com

Understanding protective immunity to facilitates preparedness for future pandemics & combats new variants emerging in the human population & phospholipid scramblase 1 (PLSCR1) as a potent cell-autonomous restriction factor against live infection in parallel -wide – screens of human lung epithelia & hepatocytes . before and after stimulation with IFNΞ³.

#IDMastodon #viralimmunology #cellimmunity #COVID19 #SarsCoV2 #genome #crispr #cas9

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1277 followers · 2490 posts · Server med-mastodon.com

@nature I’m still 😷 & It’s another friday who are till 😷 out there beside me ? A high infection rate or high by may lead to exaggerated responses, which may contribute to tissue damage in & severe .
πŸ“Œnature.com/articles/s41423-023
πŸ“Œ nature.com/cmi/

#IDMastodon #viralimmunology #cellimmunity #immunology #viralload #SarsCoV2 #cytokine #LongCovid #COVID19

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1274 followers · 2479 posts · Server med-mastodon.com

@frontimmunol new insight into the impact of virus-specific cellular immunity on the pathogenesis of and pave the way for the rational design of predictive biomarkers and therapeutic interventions. is characterized by enhanced CD4+ & diminished CD8+ T cell responses to Nucleocapsid protein @gemale10 et al
frontiersin.org/articles/10.33

#IDMastodon #neurocovid #viralimmunology #cellimmunity #LongCovid #SarsCoV2

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1274 followers · 2477 posts · Server med-mastodon.com

@eLife In this , multiple researchers with wide-ranging expertise in adult and came together to review the role of the innate and adaptive immune systems in the pathogenesis of acute infection and PASC / .The focus on immune mechanisms here emphasizes the dysregulation of immune processes that are intertwined with the and tissue-specific pathologies

#IDMastodon #clinicalreview #viralimmunology #cellimmunity #PediatricMedicine #SarsCoV2 #LongCovid #viralpersistence

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1261 followers · 2414 posts · Server med-mastodon.com

@Nature Immune genes could play a part in the risk of needing when infected with . Genetic links to inflammatory responses & the activation of immune cells β€” identifies 49 genetic variants underlying critical
πŸ“Œnature.com/articles/d41586-023
πŸ“Œnature.com/articles/s41586-023

#IDMastodon #viralimmunology #immunology #cellimmunity #ICU #SarsCoV2 #COVID19

Last updated 1 year ago

TrangAston :verified: · @CastlTrAstonDrs
1204 followers · 2186 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1185 followers · 2019 posts · Server med-mastodon.com
TrangAston :verified: · @CastlTrAstonDrs
1183 followers · 1988 posts · Server med-mastodon.com

@JEM Inherited MyD88 & IRAK-4 deficiencies are predisposed to . The patients’ susceptibility to can be attributed to impaired TLR7-dependent type I IFN production by pDCs, which do not sense correctly
πŸ“Œ rupress.org/jem/article/220/5/
πŸ“Œ rupress.org/jem/issue

#IDMastodon #immmunology #cellimmunity #innateimmunity #hypoxemic #COVID19 #SarsCoV2

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1158 followers · 1860 posts · Server med-mastodon.com

@cellcellpress
TCell exhaustion & Chronic Viral infection . All little bit alarm(in) is not always too bad! Great story about how IL-33 shapes T cell populations during chronic viral infections
cell.com/immunity/fulltext/S10

#IDMastodon #immunology #cellimmunity

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1158 followers · 1849 posts · Server med-mastodon.com

related to biological functions in .There are 113 biomarkers Cytokine/Chemokine ,Biochemical markers ,Vascular markers , Neurological markers ,Acute phase protein & Others @FrontMedicine
frontiersin.org/articles/10.33

#IDMastodon #IDtwitter #cellimmunity #immunology #clinicalreview #biomarkers #LongCovid

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1155 followers · 1832 posts · Server med-mastodon.com

@PLOSBiology LRRC15 is not a entry receptor but can suppress spike-mediated entry . LRRC15 is also expressed in fibroblast cells, the cells that control lung fibrosis, a disease which causes damaged and scarred lung tissue. can lead to lung fibrosis, and the finding may have implications for .
πŸ“Œjournals.plos.org/plosbiology/
πŸ“Œ journals.plos.org/plosbiology/

#immunology #cellimmunity #SarsCoV2 #COVID19 #LongCovid

Last updated 2 years ago

TrangAston :verified: · @CastlTrAstonDrs
1152 followers · 1827 posts · Server med-mastodon.com

Evidence suggests that adipocytes in obesity might facilitate replication, for it was only found in adipose tissue of individuals with overweight or obesity but not lean individuals who died from . in : A perfect reservoir for ?
πŸ“Œ sciencedirect.com/science/arti
πŸ“Œ sciencedirect.com/journal/medi

#IDMastodon #cellimmunity #immunology #SarsCoV2 #COVID19 #adipocytes #obesity

Last updated 2 years ago