Cystic fibrosis is caused by mutations, or changes, in the #CFTR gene. This gene provides the code that tells the body how to make the #cysticfibrosis transmembrane conductance regulator (CFTR) protein. http://www.genet.sickkids.on.ca/GenomicDnaSequencePage.html

This is the perfect day: we still need CHF 530 to reach our goal! #ScienceInAfrica #CF #CFTR
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RT @pateixidor
In our @wemakeit crowdfunding campaign we are trying to raise enough money to buy a Nanoduct® device that will improve the diagnosis of #cysticfibrosis in Africa. @AxonlabAG would you contribute in this #RareDiseaseDay2023? @SwissIonChannel @UDNIss https://wemakeit.com/projects/cystic-fibrosis-in-africa
https://twitter.com/pateixidor/status/1630494060682047488

RT @ScienceMagazine
Scientists have tied pneumonia-related #ARDS to a loss of the #CFTR protein—and show that the cystic fibrosis drug #ivacaftor can prevent CFTR loss, mitigate edema, and improve lung barrier function in mice after S. pneumoniae infection. @ScienceTM https://scim.ag/Wx

RT @ScienceMagazine@twitter.com

Scientists have tied pneumonia-related #ARDS to a loss of the #CFTR protein—and show that the cystic fibrosis drug #ivacaftor can prevent CFTR loss, mitigate edema, and improve lung barrier function in mice after S. pneumoniae infection. @ScienceTM@twitter.com https://scim.ag/Wx

🐦🔗: https://twitter.com/ScienceMagazine/status/1605775149629849601

First year PhD student Nada Elmakhzen presented in Rabat her data on sequencing the complete #CFTR gene using #Nanopore technologies. Many geneticists were impressed! #AfSHG2022 #GenomicsInAfrica #ScienceInAfrica #RareDiseases.

As additional Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the field of #CysticFibrosis: we have developed #MultiTarget compounds acting at the same time as #CFTR #Correctors and #Antibacterials or #Antivirals depending on the specific functionalization of the same chemotype.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200277
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01416