Issue 8:
Review on RNA-mediated #heterochromatin formation in our RNA focus series
Highlight on common adaptive strategies to differently induced chromosomal instability #CIN
#cGAS/STING DNA sensing activating #immunoproteasomes
#Epigenetic reprogramming in plant shade responses
Cover: Yoo Lab, RIKEN
#heterochromatin #cin #cgas #immunoproteasomes #epigenetic
DNA sensing via the #cGAS/STING pathway regulates #immunoproteasome function and #MHC class I #antigen presentation to promote #Tcell activation - with implications for the pathology of idiopathic pulmonary fibrosis
Silke Meiners et al ForschungszentrumBorstel@norden.social
#cgas #immunoproteasome #mhc #antigen #Tcell
STING directly recruits #WIPI2 for #autophagosome formation during STING-induced #autophagy - autophagy-dependent clearance of cytoplasmic DNA attenuating #cGAS-STING signaling.
#wipi2 #autophagosome #autophagy #cgas
Researchers report new mechanism in an ancient pathway of #immune response.
https://phys.org/news/2023-03-mechanism-ancient-pathway-immune-response.html
#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961
#dnadamage #DNARepair #Kinase #dnapk #cgas #inflammation #glioblastoma
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
https://www.nature.com/articles/s41586-022-05545-9
#immuneresponse #immunesystem #dna #rna #rooms #cytoplasms #cgas
#cgas #cytoplasms #rooms #rna #DNA #immunesystem #immuneresponse