A network of small RNAs regulates sporulation initiation in #Clostridioides difficile
Franziska Faber and colleagues use small RNA/target interaction mapping in the enteric pathogen C. difficile to reveal the first RNA #chaperone #Hfq-dependent RNA interactome in a gram-positive #bacterium
#clostridioides #chaperone #hfq #bacterium
Study: #Cells send #maintenance crews to fix damaged #protein factories.
https://phys.org/news/2023-04-cells-maintenance-crews-protein-factories.html
#cells #maintenance #protein #ribosomes #chaperone
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1.
#celldivision #Chromosome #staphylococcus #aureus #ftsk #chaperone #triggerfactor #septum #peptidoglycan #hydrolase
How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp
#plosbiology #hsp70 #chaperone
How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp
#plosbiology #hsp70 #chaperone
How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp
#plosbiology #hsp70 #chaperone
Die #Wissenschaft ist voll von Fällen nach dem Motto "Gut, dass jemand nochmal genauer nachgeschaut hat". Neues Beispiel: So viele #Ecoli-#Proteine wie gedacht lassen sich mithilfe von #Chaperonen gar nicht in ihre aktive Form (zurück-)falten …
— Frisch in unserem Blog: 👉 https://www.laborjournal.de/blog/?p=12859
#wissenschaft #Ecoli #protein #chaperone #proteinfaltung #biochemie
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253
#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone
How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u
#plosbiology #neurodegeneration #aging #chaperone #membraneproteins
How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u
#plosbiology #neurodegeneration #aging #chaperone #membraneproteins
How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u
#plosbiology #neurodegeneration #aging #chaperone #membraneproteins
#SomethingBeautiful #Japan Archive- Students on a field trip with a very serious chaperone, October 2019. Field trip, students and very serious chaperone- #NinenzakaSannenzakaSlope #Higashiyama #Kyoto #FieldTrip #Chaperone
#somethingbeautiful #japan #ninenzakasannenzakaslope #higashiyama #kyoto #fieldtrip #chaperone
Heterotypic phase separation of #Hfq is linked to its roles as an #RNA #chaperone:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01777-6
#microbiology #stressResponse #chaperone #rna #hfq
Hello! I am a post-doctoral researcher from the Sattler Lab at the TU Munich. I specifically work on understanding the molecular mechanisms of HSP90 and its co-chaperones on the activation of disease-relevant clients. To do so, we primary use NMR spectroscopy, integrated with other approaches such as SAXS, X-ray and Cryo-EM. I am particularly interested in protein-protein interactions, conformation changes and the study of large proteins by NMR. #introduction #NMRchat #chaperone
#chaperone #NMRchat #Introduction
How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
#bacterial #RNA #chaperone #hfq #mrnas #cryoem #ribonucleoprotein
Black Students Forced to the Back of the School Bus | https://www.theroot.com/what-year-is-it-black-students-forced-to-the-back-of-1849875592 #iowahighschoolathleticassociation #waukeecommunityschooldistrict #waukeehighschool #christiepitts #jerryfoxhoven #baileyhilson #waukee2ciowa #schoolbus #chaperone #education #iowa
#iowahighschoolathleticassociation #waukeecommunityschooldistrict #waukeehighschool #christiepitts #jerryfoxhoven #baileyhilson #waukee2ciowa #schoolbus #chaperone #education #Iowa
Chaperone code m&m’s ready to give out at #CellBio2022 😀 #chaperone #hsp70 #science
#cellbio2022 #chaperone #hsp70 #science
On my way to Manchester to meet with a casting agency, not to join but to see if I can be on their books as a chaperone. I felt like it was a pink day today. I mean most days I'm wearing pink but more than usual 😂
#chaperone #childchaperone #pink