Thiago Carvalho · @cyrilpedia
1711 followers · 8606 posts · Server qoto.orgThis is not good.
"Changes to the primary end point during or after recruitment were omnipresent in randomized clinical trials with immune checkpoint inhibitors for patients with UC, RCC, and NSCLC. Most common were switching to or adding OS as an outcome measure and subpopulations based on PD-L1 expression. Ultimately, published data often do not allow readers to infer what the results would have been if the primary outcome had not been changed."
#Immunology #Immunotherapy #immunooncology #checkpointinhibitors
#Immunooncology #checkpointinhibitors #immunology #immunotherapy
halama_immuno · @halama_immuno
290 followers · 1475 posts · Server mstdn.scienceRare #cancer treated with #Immunotherapy : new data for #sarcoma subtype angiosarcoma, treated with double #checkpointinhibitors and showing clinical effects. But we still need better #biomarkers for #precisionmedicine in #immunology ... @chfloudas @cyrilpedia
https://jitc.bmj.com/content/9/8/e002990
#cancer #Immunotherapy #sarcoma #checkpointinhibitors #biomarkers #precisionmedicine #immunology
Thiago Carvalho · @cyrilpedia
1639 followers · 6811 posts · Server qoto.org'Our studies demonstrate that in vivo trans PD-L1/CD80 interactions do exist between T and tumor cells, and in vivo blockade of trans PD-L1/CD80 interactions or general PD-L1/CD80 interactions augment tumor immunity via expansion of IFN-γ-producing CD8+T cells and NOS2+macrophages in the tumor tissues.'
#immunology #immunooncology #immunotherapy #checkpointinhibitors
#immunology #Immunooncology #immunotherapy #checkpointinhibitors
Thiago Carvalho · @cyrilpedia
1619 followers · 6315 posts · Server qoto.org'In this issue of Nature Medicine, Cascone et al.2share the latest results of their phase 2 platform trial, NEOSTAR, which suggest that the addition of CTLA-4 blockade to neoadjuvant anti-PD-1 plus chemotherapy may augment anti-tumor responses.'
#LungCancer #Immunology #TumorImmunology #immunotherapy #checkpointinhibitors
#immunology #TumorImmunology #immunotherapy #checkpointinhibitors #lungcancer
Thiago Carvalho · @cyrilpedia
1610 followers · 6103 posts · Server qoto.org"As expected, early on-target recognition of melanoma antigens by tumor-specific CD4+ T cells was required. Surprisingly, complete tumor eradication was dependent on neutrophils and partly dependent on inducible nitric oxide synthase."
#Immunology #Immunotherapy #checkpointinhibitors #Neutrophil
#immunology #neutrophil #immunotherapy #checkpointinhibitors
Thiago Carvalho · @cyrilpedia
1593 followers · 5653 posts · Server qoto.org"Over and over, trials evaluating PD-1/PD-L1 inhibitors in advanced prostate cancer have missed the mark. The failures have led to questions as to why—and have prompted oncologists to conclude that new treatment strategies are needed."
#Immunology #immunotherapy #checkpointinhibitors #prostatecancer
#prostatecancer #immunology #immunotherapy #checkpointinhibitors
Thiago Carvalho · @cyrilpedia
1573 followers · 5430 posts · Server qoto.org'We generated personalized libraries of neoantigen–HLA capture reagents to single-cell isolate the T cells and clone their T cell receptors (neoTCRs). Multiple T cells with different neoTCR sequences (T cell clonotypes) recognized a limited number of mutations in samples from seven patients with long-lasting clinical responses.'
#immunotherapy #checkpointinhibitors #immunology
Thiago Carvalho · @cyrilpedia
1542 followers · 5044 posts · Server qoto.org
ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
🎧 #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience
https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/
#EMBOPodcast #EMBOJournal #immunology #immunotherapy #checkpointinhibitors #historyofscience
IBDHorizons · @IBDHorizons
41 followers · 173 posts · Server med-mastodon.com
Thiago Carvalho · @cyrilpedia
1435 followers · 3686 posts · Server qoto.org"Here, we show that cGAMP delivery by intratumoral injection of virus-like particles (cGAMP-VLP) led to differentiation of circulating tumor-specific T cells, decreased tumor regulatory T cells (Tregs), and antitumoral responses that synergized with PD1 blockade."
#STING #Immunology #Immunotherapy #checkpointinhibitors
https://www.science.org/doi/10.1126/sciimmunol.abn6612#.Y8G4gZis1IU.twitter
#sting #immunology #immunotherapy #checkpointinhibitors
Thiago Carvalho · @cyrilpedia
1105 followers · 2349 posts · Server qoto.org'We identified three distinct types of ICI-myositis based on transcriptomic analyses. The IL6 pathway was overexpressed in all groups, the type I interferon pathway activation was specific for ICI-DM, the type 2 IFN pathway was overexpressed in both ICI-DM and ICI-MYO1, and only ICI-MYO1 patients developed myocarditis.'
#Preprint #immunotherapy #checkpointinhibitors
https://www.biorxiv.org/content/10.1101/2022.12.12.520136v1?med=mas
#preprint #immunotherapy #checkpointinhibitors
Yan Leyfman, MD · @yleyfman
89 followers · 53 posts · Server med-mastodon.com#safety #celltherapy #celltherapies #immunotherapy #genetherapy #cellulartherapeutics #IO #cancer #oncology #dlbcl #lymphoma #cartecells #cartcellrx #nkcells #nkcars #bispecifics #tcellengagers #bloodcancers #lymphoma #multiplemyeloma #solidtumors #Breastcancer #GIcancer #cartcell #cartcells #cartcellrx #msc #mesenchymalstemcells #mesenchymalstemcell #CRISPR #crisprcas9 #genetherapy #geneediting #checkpointinhibitors #bmt #bmtrx #bmtsm #tcellrx
#safety #CellTherapy #celltherapies #Immunotherapy #genetherapy #cellulartherapeutics #IO #cancer #oncology #dlbcl #lymphoma #cartecells #cartcellrx #NKcells #nkcars #bispecifics #tcellengagers #BloodCancers #MultipleMyeloma #solidtumors #breastcancer #gicancer #CARTCell #CARTCells #msc #mesenchymalstemcells #mesenchymalstemcell #crispr #crisprcas9 #geneediting #checkpointinhibitors #BMT #bmtrx #bmtsm #tcellrx
Thiago Carvalho · @cyrilpedia
922 followers · 1512 posts · Server qoto.org#Immunology #Immunotherapy
#checkpointinhibitors
"In this Review we mark the tenth anniversary of the approval of ipilimumab and discuss the foundational scientific history of ICB, together with the history of the discovery, development and elucidation of the mechanism of action of the first generation of drugs targeting the #CTLA4 and #PD1 pathways."
#immunology #immunotherapy #checkpointinhibitors #CTLA4 #pd1
Yan Leyfman, MD · @yleyfman
25 followers · 9 posts · Server med-mastodon.com#cancer #oncology #cartcell #cartcellrx #immunotherapy #genetherapy #celltherapy #immunology #cancercare #preventativemedicine #cellulartherapeutics #celltherapies #checkpointinhibitors #patientcare #patientcenteredcare #patients #support #patientsupport #advocacy #coronavirus #COVID19 #pandemic #COVID #sars_cov_2 #covid19research #pandemic2020 #SARSCoV2 #coronavirus #Corona #pandemia #cancer #oncology
#cancer #oncology #CARTCell #cartcellrx #Immunotherapy #genetherapy #CellTherapy #immunology #cancercare #preventativemedicine #cellulartherapeutics #celltherapies #checkpointinhibitors #patientcare #patientcenteredcare #patients #support #patientsupport #advocacy #coronavirus #COVID19 #pandemic #COVID #SARS_COV_2 #covid19research #pandemic2020 #SarsCoV2 #corona #pandemia