Great LIC lecture by Anne Wentink of the Leiden Institute of Chemistry and the @LED3hub to celebrate her NWO VIDI grant. She talked about her research on protein aggregation and the role of chaperones in the underlying diseases.
#Chemistry #ChemiVerse #ChemicalBiology #ChemBio #Chaperones https://doi.org/10.1038/s41586-020-2904-6

My highlights of #IUPACCHAINS2023 were talks by Hiroaki Suga, Timothy Caulfield, Ana Rita Oliveira, Seino Jongkees, Nathaniel Martin, Markus Weingarth, Heike Brötz-Oesterhelt, Peter 't Hart, Kevin Neumann, Ali Tavassoli, Tom Grossmann, Annemieke Madder, Sabine Flitsch, Gerard van Westen and Mark Distefano. #Chemistry #ChemiVerse #ChemicalBiology #ChemBio

My highlights of #IUPACCHAINS2023 were talks by Hiroaki Suga, Timothy Caulfield, Ana Rita Oliveira, Seino Jongkees, Nathaniel Martin, Markus Weingarth, Heike Brötz-Oesterhelt, Peter 't Hart, Kevin Neumann, Ali Tavassoli, Tom Grossmann, Annemieke Madder, Sabine Flitsch, Gerard van Westen and Mark Distefano. #Chemistry #ChemiVerse #ChemicalBiology #ChemBio

#IUPACCHAINS2023 comes to an end. I had an amazing time with six days of exciting science. It was great to meet so many leading scientists, make new connections, learn many new things and get inspired with new ideas for our own research. Thank you to everyone for participating. #Chemistry #ChemiVerse #ChemicalBiology #ChemBio

Great talk by Sander van Kasteren @LED3hub. He told us about his group's work on using photoactivatable, caged Flag-tags to enrich cells from specific sub-regions of tissue samples for in-depth single cell analysis. #Chemistry #ChemiVerse #ChemicalBiology #ChemBio https://www.nature.com/articles/s41589-021-00839-x

Great talk by Ana Rita Pereira Oliveira from the lab of Clemens Mayer. She talked about her work on identifying enzymes for new biocatalytic transformation using evolution and selection in intact bacteria. #Chemistry #ChemiVerse #Evolution #ChemicalBiology #ChemBio https://doi.org/10.1021/acschembio.0c00713

Great talk by Tom Grossmann at #IUPACCHAINS2023. He talked about his group's work on structural design of macrocyclic peptides and cyclized proteomimetics for binding hard targets like ß-catenin and double stranded RNA. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1002/anie.202102082

Great talk by Titia Rixt Oppewal from the group of Clemens Mayer at #IUPACCHAINS2023. She talked about her work on using evolution and selection to discover highly potent macrocyclic peptides asymmetrically cyclized with potential pharmacophores. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse #Evolution #Peptides https://doi.org/10.1021/jacs.1c12822

It was amazing to chair the "Protein Modification and ABPP" session of #IUPACCHAINS2023. Thank you to Annemieke Madder, Mark de Geus, Bob Ignacio, Max Kloet and Daan Sondag for accepting our invitations and giving such inspiring presentations. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse

Great talk by Daan Sondag of the Floris Rutjes lab in the "Protein Modification and ABPP" session of #IUPACCHAINS2023. He talked about his work on efficiently synthesizing new doubly modified trans-cyclooctanes for the TCO-tetrazine ligation. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1002/chem.202203375

Great talk by Max Kloet of the LUMC in Leiden in the "Protein Modification and ABPP" session of #IUPACCHAINS2023. He talked about his work on using ABPP to explore legionella effector proteins that lead to arginine ADP ribosylation of ubiquitin. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1021/jacs.2c06249

Great talk by Bob Ignacio from the Kim Bonger lab in the "Protein Modification and ABPP" session of #IUPACCHAINS2023. He talked about THRONCAT to specifically label newly synthesized proteins without the need for genetic engineering or specialized media. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1038/s41467-023-39063-7

Great talk by Mark de Geus in the "Protein Modification and ABPP" session of #IUPACCHAINS2023. He talked about his work in the Hackenberger lab on P(V) chemistry to rebridge disulfides in antibodies, while allowing further site-specific modification. #Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1002/anie.202205348

On the way to day 4 off #IUPACCHAINS2023. Especially looking forward to the plenary lecture by NicolaSpaldin, the talk by Sabine Flitsch, the second half of posters including one by Miriam van der Veer from our group and the NWO PI assembly in the afternoon.
#Chemistry #ChemicalBiology #ChemBio #ChemiVerse

Interesting talk by Kristine Bertheussen @LED3hub at #IUPACCHAINS2023. She talked about her research on monitoring lipids like sterculic acid using an inverse electron demand Diels-Alder reaction of the cyclopropene.
#Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1002/anie.202207640

Great talk by Mark Distefano from the University of Minnesota at #IUPACCHAINS2023. He talked about his group's work on protein prenylation. Interesting insights e.g. into inhibitors of farnesyltransferases as antifungals and into studying the prenylome in vivo.
#Chemistry #ChemicalBiology #ChemBio #ChemiVerse https://doi.org/10.1021/acs.jmedchem.2c00902

@SingingNala

Some of these probably won't interest you (I'm a chemist, but I know not everyone wants their feed to have random chemistry papers sprinkled in it ⚗️ )

I follow (or see often)
#Baking #Cooking
#Chemistry #ChemiVerse #ChemicalBiology #ChemBio #Science #Biking #BikeTooter #CarryShitOlympics
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🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to quantify discrete steps in this network, mediated by lipid transfer proteins working at membrane contact sites between different organelles. We (Dongjun Liang & Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a family of lipid transfer proteins at these contact sites! https://doi.org/10.1101/2023.02.01.526230 #lipidtime #chembio

It was with great sadness that I heard of the death of Prof. Christopher Walsh today. He was a giant in #Chembio and also wonderful to interact with. I know there are many who trained with him and his impact in the field will continue on through them. #RIP #Chemistry #chemicalbiology #chemiverse

Announcement I've been sitting on: I'm joining UCI's new Institute for Neurotherapeutics! While Rob Spitale (@SpitaleLab@twitter.com) is affiliated with the INT he is on leave from the university (hence my job change) and I'll be working for Brian Paegel (@BrianDNA@twitter.com) and INT director Al La Spada.

https://news.uci.edu/2022/10/18/uci-launches-center-for-neurotherapeutics-to-facilitate-drug-discovery-and-therapy-delivery/

#UCI #Neurotherapeutics #Chemistry #ChemicalBiology #ChemBio #ChemiVerse #MedChem #MedicinalChemistry #DrugDiscovery #Collaboration #Science