New vaccines on the horizon for travellers: #chikungunya and #dengue

#TravelMedicine #VaccinesWork #IDMastodon

https://link.springer.com/article/10.1007/s11908-023-00811-x

"One or two tendrils, sometimes as long as the cell itself, snake outwards, at times toward uninfected cells. And these tendrils can escape attack by the immune system."

#Chikungunya virus surges in South America. But a new discovery could help outfox it

https://www.npr.org/sections/goatsandsoda/2023/08/18/1194392519/chikungunya-virus-surges-in-south-america-but-a-new-discovery-could-help-outfox

#IDMastodon #CHIKV

https://france3-regions.francetvinfo.fr/occitanie/haute-garonne/toulouse/moustiques-tigres-la-dengue-le-zika-le-chikungunya-ces-maladies-auxquelles-nous-ne-pourrons-probablement-pas-echapper-dans-le-futur-2826341.html

#dengue #zika #moustiquetigre #chikungunya #arbovirose

Initial findings from a large clinical trial testing a vaccine against the chikungunya virus show the vaccine generates protective antibodies in the vast majority of recipients.

https://sciencebusiness.technewslit.com/?p=45079

#News #Press #Science #Business #Biotechnology #Chikungunya #Virus #Mosquitoes #Fever #ClinicalTrial #Antibodies #Placebo #AdverseEffects #Efficacy #Denmark

Gute Neuigkeiten zum ersten #Impfstoff gegen das #Chikungunya-Virus. In einer im Lancet publizierten Zulassungsstudie. Nach einer einmaligen Impfstoffgabe hatten die Probanden einen anhaltend hohen Antikörperschutz für den gesamten Beobachtungszeitraum von 180 Tagen.

Das Virus gehört zu den sogenannten "Tropenkrankheiten", die sich aufgrund der #Klimawende bereits nach Südeuropa ausgebreitet und inzwischen auch schon vereinzelt Mitteleuropa betreffen. Wohl ein Grund, warum bei den Impfungen jetzt was weiter geht.

https://www.spektrum.de/news/virusvakzin-impfstoff-gegen-chikungunyavirus-kurz-vor-zulassung/2148780

New chikungunya vaccine: Climate change may spread demand

https://www.dw.com/en/new-chikungunya-vaccine-climate-change-may-spread-demand/a-65908307?maca=en-dipa_news_mstdn-34613-xml-mrss

#vaccine #mosquitoes #malaria #chikungunya #vaccination #virus #climatechange #globalwarming #disease

Vacina candidata contra chikungunya apresenta resposta imune em 99% dos participantes, segundo estudo na Lancet. Resultados promissores, porém mais estudos são necessários em regiões endêmicas. #Chikungunya #Vacinação #Saúde
https://g1.globo.com/saude/noticia/2023/06/13/candidata-a-vacina-contra-chikungunya-e-segura-e-eficaz-com-apenas-uma-dose-imunizante-e-testado-no-brasil.ghtml

New research article in The Lancet>

Safety and immunogenicity of a single-shot live-attenuated #chikungunya #vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00641-4/fulltext

In what could be a major breakthrough, a human clinical trial of a vaccine candidate to prevent #chikungunya has returned a 99% immune response.

(Reports @RamblingBrook)

https://www.hindustantimes.com/india-news/chikungunya-vaccine-trial-shows-99-immune-response-in-human-clinical-trial-101686597171710.html #press

A vaccine for #chikungunya based on virus-like particles induces strong responses in humans and generates neutralizing antibodies that protect mice against multiple #alphaviruses, shows an analysis of a phase 2 trial. https://scim.ag/2MP @ScienceTM #press

A vaccine for #chikungunya based on virus-like particles induces strong responses in humans and generates neutralizing antibodies that protect mice against multiple #alphaviruses, shows an analysis of a phase 2 trial. https://scim.ag/2Kd @ScienceTM #press

The May, and 3rd anniversary 🎂, issue of The Lancet Microbe is now online:

https://thelancet.com/journals/lanmic/issue/current

The journal is #OpenAccess, so you are free to explore all of the content, but these hashtags offer a flavour:

#pertussis #COVID19 #SARSCoV2 #chikungunya #pneumonia #RSV #influenza #tuberculosis #TB

To round off #WorldImmunisationWeek check out the recent review from Filipa Henderson, Peter Barlow & colleagues that discusses advances in #vaccines for #chikungunya - an understudied #mosquito borne #virus with increasing global infections and impact 🦟

📰https://journals.biologists.com/dmm/article/16/4/dmm049804/301041/
@EdinburghNapier #EdinburghNapierUniversity

'In this Primer, we outline the current understanding of #chikungunya fever based on research in patients and animal models, which have provided considerable insights into the complex spectrum of disease manifestations and the mediators of arthritic immunopathology.'

#Immunology #virology
https://www.nature.com/articles/s41572-023-00429-2

New research article in The Lancet Microbe>

Spatiotemporal dynamics and recurrence of #chikungunya virus in #Brazil: an epidemiological study

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00033-2/fulltext

"Climate change spurring surge in dengue, chikungunya

The World Health Organization warned Wednesday that dengue and other diseases caused by mosquito-borne arboviruses were spreading far faster and further amid climate change, warning global outbreaks could be looming.

Experts with the United Nations health agency sounded the alarm over swelling numbers of cases of dengue and chikungunya, and warned new epidemics of zika could also be expected.

All three are caused by arboviruses carried by Aedes aegypti mosquitos, which have been spreading into new territory as the planet warms."

#ClimateChange #GlobalWarming #WHO #dengue #chikungunya #zika #AedesAegypti #mosquito

🔗: https://medicalxpress.com/news/2023-04-climate-spurring-surge-dengue-chikungunya.html

#WHO (23 March 2023). Disease Outbreak News; Geographical #expansion of cases of #dengue and #chikungunya beyond the historical areas of #transmission in the Region of the Americas. Available at https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON448

''It is also noted that selective studies have shown the prevalence of viruses that cause #dengue and #chikungunya fevers in the north of #Tanzania, and in 2022 an #outbreak of #leptospirosis was recorded in the country.'', another source said.

RT @rubueno10
🦟🦠 Desgraciadamente este va a ser el año del #Chikungunya y vamos a hablar mucho de él: alerta epidemiológica lanzada por la @opsoms en las #Américas
💉 Vamos a tener que trabajar intensamente en el diagnóstico diferencial y no confundir con #Dengue, qué también está en auge 😓

Casos de #chikungunya en #Paraguay saturan las capacidades #pediátricas https://boletinaldia.sld.cu/aldia/2023/03/03/casos-de-chikungunya-en-paraguay-saturan-las-capacidades-pediatricas/