In our monthly Classic Papers in HIV journal club, Episode 19, https://research.fredhutch.org/emerman/en/courses/classic-papers-in-hiv-biology-journal-club.html we discussed papers establishing that lentiviruses (the type of virus that includes HIV) have infected at least some primates for millions of years through the finding of copies of an ancient lentiviral infection in the genomes of Malagasy Lemurs. https://doi.org/10.1073/pnas.0807873105 and https://doi.org/10.1371/journal.pgen.1000425 #Virology #HIV #ClassicPaperJournalClub #Science 1/7

In our monthly Classic Papers in HIV journal club, Episode 18, https://research.fredhutch.org/emerman/en/courses/classic-papers-in-hiv-biology-journal-club.html we discussed a paper that firmly established that the HIV1 capsid protein (CA) plays an active role in the early steps of HIV-1 infection. https://doi.org/10.1016/j.chom.2010.02.007 #Virology #HIV #ClassicPaperJournalClub #Science 1/5

In our monthly Classic Papers in HIV journal club, Episode 17, https://research.fredhutch.org/emerman/en/courses/classic-papers-in-hiv-biology-journal-club.html , we discussed two papers that describe the specificity of HIV-1 integration into the actively transcribed genes of the human genome due to the binding of a host protein, LEDGF to the HIV-1 integrase protein. https://doi.org/10.1038/nm1329 and
https://doi.org/10.1073/pnas.0914142107 #Virology #HIV #ClassicPaperJournalClub #ScienceSunday 1/7

In our monthly Classic Papers in HIV journal club, Episode 16, we discussed two papers from 2011 that simultaneously described the discovery of SAMHD1 as the target of the viral protein X (Vpx) to allow lentivirus infection of macrophages and dendritic cells. https://www.nature.com/articles/nature10117 from the Benkirane group and https://www.nature.com/articles/nature10195 from the Skowronski group. #Virology #HIV #ClassicPaperJournalClub #ScienceSunday 1/7

In our monthly Classic Papers in HIV journal club this week, Episode 15, we discussed two papers that came out about the same time that describe the discovery of Tetherin/Bst-2 as the target of HIV-1 Vpu in enabling virus release from cells. "Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu” and "The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein” . #Virology #HIV #ClassicPaperJournalClub 1/8

There are 14 sessions now, and ~6 more planned. I would like to recreate the previous birdsite posts (example here of the most recent: https://mstdn.science/@memerman/109457724243075699), but not sure what is the best venue for that. Any suggestions? Substack? Also, my list is biased towards my expertise in molecular virology, so it might be very interesting for someone to start a parallel list in HIV clinical trials, epi/public health. #ClassicPaperJournalClub #Virology

In our monthly Classic Papers in HIV journal club last week, we discussed two papers from the Sundquist group that established that HIV-1 usurps cellular machinery involved in membrane vesicle sorting for budding out of cells.
"Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding” https://doi.org/10.1016/S0092-8674(01)00506-2 and "The Protein Network of HIV Budding" https://doi.org/10.1016/S0092-8674(03)00714-1
#Virology #HIV #ClassicPaperJournalClub 1/9